Feast your eyes on the fried egg nebula

Tuesday 1 October 2013

Islamabad, Oct 2 (Newswire): Astronomers have used ESO's Very Large Telescope to image a colossal star that belongs to one of the rarest classes of stars in the Universe, the yellow hypergiants.

The new picture is the best ever taken of a star in this class and shows for the first time a huge dusty double shell surrounding the central hypergiant. The star and its shells resemble an egg white around a yolky center, leading the astronomers to nickname the object the Fried Egg Nebula.

The monster star, known to astronomers as IRAS 17163-3907 [1], has a diameter about a thousand times bigger than our Sun. At a distance of about 13 000 light-years from Earth, it is the closest yellow hypergiant found to date and new observations show it shines some 500 000 times more brightly than the Sun [2].

"This object was known to glow brightly in the infrared but, surprisingly, nobody had identified it as a yellow hypergiant before," said Eric Lagadec (European Southern Observatory), who led the team that produced the new images.

The observations of the star and the discovery of its surrounding shells were made using the VISIR infrared camera on the VLT. The pictures are the first of this object to clearly show the material around it and reveal two almost perfectly spherical shells.

If the Fried Egg Nebula were placed in the centre of the Solar System Earth would lie deep within the star itself and the planet Jupiter would be orbiting just above its surface. The much larger surrounding nebula would engulf all the planets and dwarf planets and even some of the comets that orbit far beyond the orbit of Neptune. The outer shell has a radius of 10 000 times the distance from Earth to the Sun.

Yellow hypergiants are in an extremely active phase of their evolution, undergoing a series of explosive events -- this star has ejected four times the mass of the Sun in just a few hundred years [3]. The material flung out during these bursts has formed the extensive double shell of the nebula, which is made of dust rich in silicates and mixed with gas.

This activity also shows that the star is likely to soon die an explosive death -- it will be one of the next supernova explosions in our galaxy [4]. Supernovae provide much-needed chemicals to the surrounding interstellar environment and the resulting shock waves can kick start the formation of new stars.

The Very Large Telescope mid-IR instrument, VISIR, captured this delicious image of the Fried Egg Nebula through three mid-infrared filters that are here coloured blue, green and red.
 [1] The name indicates that the object was first spotted as an infrared source by the IRAS satellite in 1983 and the numbers show the star's place in the sky, in the heart of the Milky Way in the constellation of Scorpius (The Scorpion).

[2] IRAS 17163-3907 is one of the 30 brightest stars in the infrared sky, at the wavelength of 12 microns observed by IRAS, but it had been overlooked because it is quite faint in visible light.

[3] The total mass of this star is estimated to be roughly twenty times that of the Sun.

[4] After burning all their hydrogen all stars of ten solar masses or more become red supergiants. This phase ends when the star has finished burning all of its helium. Some of these high-mass stars then spend just a few million years in the post-red supergiant phase as yellow hypergiants, a relatively short time in the life of a star, before rapidly evolving into another unusual type of star called a luminous blue variable. These hot and brilliant stars are continuously varying in brightness and are losing matter due to the strong stellar winds they expel. But this is not the end of the star's evolutionary adventure, as it may next become a different kind of unstable star known as a Wolf-Rayet star, before ending its life as a violent supernova explosion.

[5] The three mid-infrared filters that were used passed light at wavelengths around 8590 nm (coloured blue), 11 850 nm (coloured green) and 12 810 nm (coloured red).

This research is presented in a paper "A double detached shell around a post-Red Supergiant: IRAS 17163-3907, the Fried Egg nebula " by E. Lagadec et al., submitted to the journal Astronomy & Astrophysics.
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Pigeon 'milk' contains antioxidants and immune-enhancing proteins

Islamabad, Oct 2 (Newswire): Production of crop milk, a secretion from the crops of parent birds, is rare among birds and, apart from pigeons, is only found in flamingos and male emperor penguins.

Essential for the growth and development of the young pigeon squab, pigeon 'milk' is produced by both parents from fluid-filled cells lining the crop that are rich in fat and protein.

Research published in BioMed Central's open access journal BMC Genomics uses new technology to study the genes and proteins involved in pigeon 'milk' production and shows that pigeon 'milk' contains antioxidants and immune-enhancing proteins.

Researchers from CSIRO Livestock Industries and Deakin University, Australia, compared the global gene expression profiles of the crops of four 'lactating' and four 'non-lactating' female pigeons. As the pigeon genome has not yet been sequenced, they used a chicken microarray to find the genes involved. Genes predominantly over-expressed in 'lactating' birds were those involved in stimulating cell growth, producing antioxidants and in immune response. They also found genes associated with triglyceride fat production, suggesting the fat in the 'milk' is derived from the pigeon's liver.

Lead author, Meagan Gillespie, says, "It is possible that if antioxidant and immune proteins are present in pigeon 'milk', they are directly enhancing the immune system of the developing squab as well as protecting the parental crop tissue."

She continues, "This study has provided a snap-shot view of some of the processes occurring when 'lactation' in the pigeon crop is well established. Due to the unusual nature of 'lactation' in the pigeon it would be interesting to investigate the early stages of the differentiation and development of the crop in preparation for 'milk' production to further ascertain gene expression patterns that characterize crop development and 'lactation' in the pigeon."

She concludes, "This mechanism is an interesting example of the evolution of a system with analogies to mammalian lactation, as pigeon 'milk' fulfills a similar function to mammalian milk."
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Hide-and-seek: Altered HIV can't evade immune system

Islamabad, Oct 2 (Newswire): Researchers at Johns Hopkins have modified HIV in a way that makes it no longer able to suppress the immune system.

Their work, they say in a report published in the journal Blood, could remove a major hurdle in HIV vaccine development and lead to new treatments.

"Something about the HIV virus turns down the immune response, rather than triggering it, making it a tough target for vaccine development," says David Graham, Ph.D., assistant professor of molecular and comparative pathobiology and medicine. "We now seem to have a way to sidestep this barrier," he adds.

Typically, when the body's immune system cells encounter a virus, they send out an alarm by releasing chemicals called interferons to alert the rest of the body to the presence of a viral infection. When the immune cells encounter HIV, however, they release too many interferons, become overwhelmed and shut down the subsequent virus-fighting response.

The researchers had learned from other studies that when human immune cells (white blood cells) are depleted of cholesterol, HIV can no longer infect them. It turns out the coat that surrounds and protects the HIV viral genome also is rich in cholesterol, leading the Johns Hopkins team to test whether viruses lacking cholesterol could still infect cells at all.

The researchers treated HIV with a chemical to remove cholesterol from the viral coat. Then they introduced either the cholesterol-diminished or normal HIV to human immune cells growing in culture dishes, and measured how the cells responded. The cells exposed to cholesterol-diminished HIV didn't release any initial-response interferons, whereas the cells exposed to normal HIV did.

"The altered HIV doesn't overwhelm the system and instead triggers the innate immune response to kick in, like it does with any first virus encounter," says Graham.

Next, the researchers checked to see if cholesterol-diminished HIV activates so-called adaptive immune responses -- the responses that help the body remember specific pathogens long-term so the body develops immunity and counters future infections. To do this, they put normal HIV or cholesterol-diminished HIV into blood samples, which contain all the different cells needed for an adaptive immune response.

More specifically, they tested blood samples from people with previous exposure to HIV in order to see if their blood could mount an adaptive immune response. Blood samples were used from 10 HIV positive people and from 10 people repeatedly exposed to HIV who weren't infected. The researchers didn't expect the HIV-positive blood to respond to either version of HIV because of the severely damaged immune systems of HIV patients. However, when cholesterol-diminished HIV was introduced to the non-infected HIV blood in a tube, the cells of the adaptive immune response reacted against the virus. By altering the virus, explains Graham, the researchers were able to reawaken the immune system's response against HIV and negate HIV's immunosuppressive properties.

"In addition to vaccine applications, this study opens the door to developing drugs that attack the HIV viral coat as an adjunct therapy to promote immune system detection of the virus," says Graham.
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