Sweden pledges one billion USD to Afghanistan over next decade

Wednesday 10 July 2013

Kabul, July 11 (Newswire): The Swedish International Development Agency (SIDA) promised over one billion USD in aid to Afghanistan over the next 10 years.

SIDA officials gathered in Mazar-e-Sharif said that the aid funds would be dedicated to development in the fields of democracy, education and human rights.

"Sweden has been in Afghanistan for many years working primarily in two areas, one being human rights and the other democracy, and this assistance will continue in the coming years," said Charlotte Peter Lodi, the head of SIDA.

Ninety-three million USD will be allocated to support these areas in the next year alone.

However, Ms. Lodi expressed concern over administrative corruption in Afghanistan. She said she hoped that the Afghan government would work concertedly to eliminate what is now pervasive corruption in public institutions throughout the country, though she assured that Sweden would not stop its aid.
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Kabul property boom confounds fears about Afghanistan's security

Kabul, July 11 (Newswire): Two giant concrete pomegranates loom over downtown Kabul, with bright red, 15ft-tall seeds bursting from their sides and lit at night with dancing pink lights.

The sculptures adorn the top of the orange, silver and blue "Pomegranate Towers" apartment block, one of the more garishly ostentatious buildings thrown up by Kabul's nouveau riche but also an unlikely token of hope in city threatened by a tenacious insurgency as foreign troops leave.

"I get a lot more confidence from looking at these awful buildings. It kills me as an architect, but from an economic point of view it seems to be quite a vote of confidence," said Jolyon Leslie, a South African with several decades experience of restoration and urban planning in Afghanistan. "Everyone is talking about the tide going out economically, but everyone is still investing in these fancy buildings … they are making a long-term bet the city will stay stable enough to earn it back."

Builder Faizullah Barakzai's tower, which pays tribute to his hometown of Kandahar, famous for its autumn crop of sweet, juicy pomegranates, is part of a building boom that has transformed the Afghan capital in little more than a decade.

"There is a lot of negative propaganda, but I think that eventually the rich Afghans who take money out of the country will regret it," Barakzai said after a tour of his glitzy penthouse suite.

Once a sleepy mountain town of low-rise homes, Kabul's smartest areas are now a grid of multicoloured, multi-storey family palaces studded with mirrors and stucco, one even boasting a rooftop lion enclosure.

The rich gather to celebrate their children's unions at opulent wedding halls, one guarded by golden elephants, another by a looming model of the Eiffel tower. There are bowling alleys, supermarkets crammed with imported clothes and food, and leisure centres with pools and saunas.

The lavish lifestyle has been funded by an influx of foreign money and the proceeds from drugs, which have enriched a tiny elite while most of the country still grapples with desperate poverty, malnutrition, illiteracy and some of the lowest-life-expectancy in the world.

Nato combat troops will be gone by the end of 2014 and as they head home, spending is shrinking. There is widespread fear that Afghanistan faces economic collapse, a security vacuum and a repeat of the civil war that ripped the country apart in the 1990s.

Rents and land prices in the capital have fallen as people hedge their bets and opt for more portable investments. That choice is made easier in a country where tracking of wealth is in its infancy, as evidenced by a former vice-president who once flew to a Gulf state with $52m (£34m) in cash, according to a US diplomatic cable published by WikiLeaks.

Trust in the financial system was further undermined with the near-collapse of the top private lender Kabul Bank in 2010, amid a $900m corruption scandal, exposing a web of dubious assets including a clutch of villas in Dubai.

Rather than experiencing a slowdown in its frenetic building sector, however, Kabul is increasingly overrun with precarious apartment blocks. Cement and brick walls climb ever higher in defiance of planning laws, frequent earthquakes and the threat of war. If cranes are a benchmark of economic growth, then this city is booming.

"The phrase '2014' is a form of psychological warfare," said builder Hasan Ali Sakhizada, who has invested around $1m in a block of apartments for rent and sale, and a luxurious home. "It's not going to have an effect on the property market, because people still need somewhere to live.

"Everyone says the Americans are leaving but they are not. They have invested too much in Afghanistan. The current problems are just politics by the US to help them negotiate their strategic pact [for a long-term military presence]."

The new buildings are a dramatic contrast to the muted colours and elaborate handicrafts that adorned the homes of Afghanistan's traditional elite, hidden behind high, plain walls.

The new rich want their wealth on show. "After we finished work on the pomegranates, someone driving past had a road accident because he was staring at them," Barakzai said with obvious pride.

He has personally furnished the penthouse apartment, reached by a gold-lined lift, with plush leather furniture, ceilings swept with gilt and carving, shining parquet floors, cabinets of curios and statues backlit in neon pink, green and blue, and a television that responds to voice commands.

"I wanted to make it as luxurious as possible," said Barakzai in a tiny office at the base of the tower, where staff drank sweet, milky coffee he swore was the best in Kabul, and cans of Red Bull.

"One of my dreams is that the homes which are mud will all be concrete and beautiful, like buildings in our neighbours India and Pakistan. In other countries there are a lot of tall buildings, so I wanted to do something similar for Afghanistan."

The country's new rich may like to show off their wealth, but they are less keen about discussing where it came from. Barakzai said his apartment plot was built on family land that once held a bungalow and garden, building on a long family history of entrepreneurship.

Funding came from advanced sales of apartments, he said, even though he put the average unit price at a modest $90,000, and admitted that his commercial empire now includes another construction site near Kabul's parliament and a wedding hall, hospital and supermarket in southern Kandahar.

The Barakzai family clearly have powerful connections. Among the vehicles in the basement car park are those of a deputy provincial governor and a senior intelligence official, both among the new tenants of the 32 apartments.

Their luxury armoured SUVs are a subtle boast of Barakzai's impressive neighbours, but may also hold a clue to one prop for the Kabul property boom as western cash dries up and an escalation of violence looms.

"It used to be you had a guest house where people could stay, and your wealth would be judged by the number of guests who could sit down to dinner," said Leslie. "This is a latter-day way of dispensing patronage, because I'm sure the tenants aren't paying full market rate."
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US-built schools in Afghanistan pose ‘potentially life-threatening risks’

Kabul, July 11 (Newswire): Two schools that the US government built in Afghanistan are so unsafe that they are placing the lives of Afghan students and teachers at risk, according to a U.S. government inspection.

"An urgent safety matter has come to my attention that I believe requires your immediate action. Specifically, I want to alert you to potentially life-threatening risks at the Bathkhak School addition in the Bagrami district, Kabul province, Afghanistan," John Sopko, the Special Inspector General for Afghanistan Reconstruction (SIGAR), wrote in a letter released to ISAF Command Gen. Joseph Dunford.

The SIGAR office, which oversees U.S.-funded reconstruction projects in Afghanistan, inspected the school and is preparing a report, but felt the need to alert U.S. officials to the construction problems at the school immediately because the danger to the students is imminent.
"Specifically the school's interior and exterior walls appear to be insufficiently constructed to hold the weight of the concrete ceiling," Sopko wrote.

The ceiling and roof were made of concrete, not wood and sheet metal as the contract specified. The brick walls of the school may not be able to support that ceiling, and because the area is earthquake prone, the school might collapse if there is any seismic activity, according to the SIGAR office.

"In light of these construction flaws and the distinct possibility that an earthquake resistant design was not used, we have serious concerns for the safety of the hundreds of faculty and children that will be using the classrooms at any given time," Sopko wrote.

Citing a "serious risk" that the building could collapse," SIGAR is asking the U.S. government not to transfer the building over to Afghan control and to alert the Afghan education ministry that the building is unsafe.

In a separate letter, Sopko wrote to the head of the Army Corps of Engineers and the leadership of USAID to alert them about another unsafe building built by the U.S, the Sheberghan teacher training facility in Jawzjan province, Afghanistan.

One building is at risk of erupting into flames due to substandard electrical wiring, SIGAR found.

This building is at risk of erupting into flames due to substandard electrical wiring, SIGAR found. The building also has poor water and sewage systems that could pose health risks to the people there.

"SIGAR inspectors found that the facility's electrical wiring does not meet the U.S. National Electrical Code as required by the contract and other problems that create potential electrocution risks and fire hazards for its occupants," Sopko wrote.

That building is still under construction, but the Afghans have already begun using it, according to the letter. SIGAR plans to go back and conduct more extensive inspections at both sites, but Sopko didn't want to wait before warning U.S. officials that the two sites were dangerous and steps need to be taken now.

"Given the potential harm to the students, faculty, and others who are occupying the Sheberghan facility, we believe USAID should take all necessary and appropriate measures to address the safety risks discussed in this letter as soon as possible," he wrote.
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How immigration votes changed between 2010 and 2013, in charts

Washington, July 11 (Newswire): The historic Senate vote on immigration fell a bit short of the 70 votes supporters hoped for. But a two-to-one margin in the final 68-32 margin is still an accomplishment in a body that rarely sees controversial measures pass. And it's even more remarkable when compared to the 2010 Senate vote on the DREAM Act.

Admittedly, the DREAM Act was a much more liberal piece of policy. The bill voted was intentionally crafted by eight senators from both parties to have broader appeal. To that end it was largely, but not entirely, successful. Seventy-three senators voted on both the DREAM Act and the new immigration measure. Of those, the vast majority voted the exact same way both times, either in opposition or in support. Where senators changed votes, though, is telling.

This chart shows those 73 senators' votes, plotted on a grid. The upper left corner is those who supported both measures; lower right, those who opposed both. What's interesting is the other two boxes. In the upper right box are all of the senators who opposed today's measure but supported the DREAM Act — precisely none of them. The other box is the reverse, those who opposed the DREAM Act but voted "yes" today.

Those switched votes aren't the only thing that made a difference, however. The chart below shows votes from senators who only voted on one of the two bills — either because they left office or only came into office between the two votes. The two lefthand clusters below are votes for and against the DREAM Act; the two on the right are votes for and against today's bill.

It's immediately clear that today's vote had much more support from both parties among the new senators. Every Democrat voted for it, and far more Republicans did than voted only for the DREAM Act.

Again: today's success wasn't only due to a change of heart on the part of those twelve senators in that lower lefthand box. It's a much more moderate bill, one aimed at enticing the House to lend its support. How that vote will play out is much harder to calculate.
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Reports: Retired general target of leaks probe

Washington, July 11 (Newswire): A former vice chairman of the Joint Chiefs of Staff is under investigation for allegedly leaking classified information about a covert cyberattack on Iran's nuclear facilities, according to media reports.

Retired Marine Gen. James "Hoss" Cartwright has been told he is a target of the probe, NBC News and The Washington Post reported. A "target" is someone a prosecutor or grand jury has substantial evidence linking to a crime and who is likely to be charged.

The Justice Department referred questions to the U.S. attorney's office in Baltimore, where a spokeswoman, Marcia Murphy, declined to comment.

The investigation of the leak about the Iran cyberattack is one of a number of national security leak investigations that have been started by the Obama administration.

In June 2012, the New York Times reported that Cartwright was a crucial player in the cyber operation called Olympic Games, started under President George W. Bush.

Bush reportedly advised President Barack Obama to preserve Olympic Games.

According to the Times, Obama ordered the cyberattacks sped up, and in 2010 an attack using a computer virus called Stuxnet temporarily disabled 1,000 centrifuges that the Iranians were using to enrich uranium.

Congressional leaders demanded a criminal probe into who leaked the information, and Obama said he had zero tolerance for such leaks. Republicans said senior administration officials had leaked the details to bolster the president's national security credentials during the 2012 campaign.

The Times said Cartwright was one of the crucial players who had to break the news to Obama and Vice President Joe Biden that Stuxnet at one point had escaped onto the Internet.

An element of the program accidentally became public in the summer of 2010 because of a programming error that allowed it to escape Iran's Natanz plant and sent it out on the Internet, the Times reported. After the worm escaped onto the Internet, top administration officials met to consider whether the program had been fatally compromised.

Obama asked if the program should continue, and after hearing the advice of top advisers, decided to proceed.

Cartwright, a four-star general, was cleared in February 2011 of misconduct involving a young aide. An anonymous accuser had claimed Cartwright acted inappropriately during a 2009 overseas trip on which the aide traveled as a military assistant. Several sources confirmed that the former aide was a young woman.

The Pentagon inspector general quickly cleared Cartwright of the most serious allegations, which involved claims that he may have had an improper physical relationship with the woman. The report did find that Cartwright mishandled an incident in which the aide, drunk and visibly upset, visited his Tbilisi, Georgia, hotel room alone and either passed out or fell asleep on a bench at the foot of his bed. Cartwright denied any impropriety and was later cleared of all wrongdoing.

Cartwright, once considered the leading candidate to become Joint Chiefs of Staff chairman, resigned from the military in August 2011.

NBC said Cartwright did not respond to request for comment and that his attorney, former Obama White House counsel Greg Craig, said he had no comment.
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On immigration, celebrating a job half done

Washington, July 11 (Newswire): It had all the optics of a truly historic day. Vice President Joe Biden presided over the Senate vote that would reform the country's broken immigration system and help provide a pathway to citizenship for 11 million people living here illegally.

The gallery was full, including dozens of young Hispanic men and women wearing blue and orange shirts with slogans like "11 Million Dreamers."

And yet, when Biden gaveled in the final vote, there was just a smattering of applause. The crowd mustered a chant of "yes we can," before being told to be quiet by Biden, and everyone walked out of the galleries. As big a deal as this vote was—and by modern Senate standards it was quite an accomplishment—the day's celebration is very much tempered by the chaos that lies ahead.

With the Republicans in the House having already labeled the bill dead on arrival, it was difficult for the Senate to believably celebrate their achievement. When six members of the Gang of Eight held a press conference after the vote, it felt a bit like a baseball team celebrating getting to the World Series without knowing for sure if it was going to be playing anyone.

But that didn't stop the senators from lavishing praise on one another (the press conference began with a literal back slap laid on Sen. John McCain from Sen. Chuck Schumer). "We all gave. We all Took. We all fought. We all smiled. And at the end of the day we held hands and walked out here together," Schumer said. And at the end of the press conference, he walked arm-in-arm with McCain, very aware that a group of a half dozen photographers were snapping their photos. For posterity. Or something.

That image of bi-partisan unity is not an accident. For comprehensive immigration reform to have a chance, the Senate needs to make the House feel like it has unstoppable momentum behind it. But as much as the 68 Senators who supported the bill would like it to look like there was near-unanimous consent, that's was not the case.

Sen. Jeff Sessions, for example, spent part of his day in a Senate office building rotunda, a tall blond woman from the Tea Party News Network towering over him with her arm around his shoulder.

"Sorry that took so long, I could just talk to you all day," the interviewer told Sessions with a laugh. The Alabaman has become the face of the GOP objection to the Senate bill, telling almost anybody who will ask what he thinks is wrong with it (well, almost anybody. After talking to TPNN, he refused an interview with Telemundo, the Spanish language channel).

"This bill is just made up of poll-tested talking points," Sessions told me as he walked toward his office. "As legislation, it's not nearly effective enough. A bill is not what the talking points say it is, it's what's in it."

This line of thinking, the idea that the border needs to be made more secure ahead of anything else puts him in line with much of the thinking down the Hall in the House of Representatives.

"You want to know if this is a historic vote or not?" Rep. Raul Grijalva, D-Ariz., said standing outside in the rain on his way to his office after a press conference. "That depends on what House leadership does with the responsibility they've been given. If they produce a bipartisan bill, and if Boehner were to allow it on the floor, than this day could be looked at as historic."

"If" was the operative word there.

"I just wish now I could go over to the House for a few months and work this out over there," said Sen. Jeff Flake, a Republican member of the Gang, and recent defector from the House.

Despite the bill's shaky prospects, don't try to tell the senators that supported the bill they didn't do something momentous. When McCain and Sen. Lindsey Graham came out of the Senate subway on their way to a morning vote, they were greeted like celebrities.

"Immigration reporters, swarm!" shouted David Grant, a reporter at the Christian Science Monitor—much to chagrin of harried Senate staffers who urged the crowd to "make a lane."

"That's the opposite of what we want to do," Grant told me. "We're looking to make a barricade."

Everywhere Graham went, he reporters clustered around him. But with a new haircut, and plenty of talking points in his pocket ("Self-deportation as a Republican Policy is in our rear view mirror"), he was ready for it.

When I caught up with him after he escaped from the crowd, he had a little bit of spittle stuck on the side of his mouth from talking so much, but he was smiling. "I get underwhelmed a lot, it's not very often that I get overwhelmed," he said. "It's a big day that shows the Senate is back in business."

Sen. Rob Portman, the Ohio Republican, was one of the only question marks going into the day's vote. Running out of his office to get to a meeting he says, "I've been late to everything all day. I've got too much going on."

Portman couldn't share in the (temporary) victory. He voted against the bill after his amendment failed.

"I definitely don't think my constituents think of me as all-powerful," he lamented. "It's a frustrating job," he said.

In the midst of a day of high-fiving and backslapping, I asked Mo Cowan, who is finishing up tenure as the fill-in senator from Massachusetts, what it was like going out on such a historic vote.

"Which vote are you talking about?" he replied. "Oh, immigration! I thought you were talking about the Anthony Foxx confirmation."
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DOMA plaintiff backs Quinn for NYC mayor

New York, July 11 (Newswire): With just over two months to go before the primary, the endorsements are starting to roll in for the candidates vying to replace New York City Mayor Michael Bloomberg.

Christine Quinn received a surprise endorsement from Edith Windsor, the plaintiff in the case that prompted the Supreme Court to strike down the Defense of Marriage Act. Windsor's endorsement came during a rally held just hours after the court's decision outside the historic Stonewall Inn in Manhattan when she jumped onstage to join Quinn, who is gay, and announced she was supporting the City Council speaker's bid for mayor.

"I was committed to not endorse anyone until there was a decision" on DOMA, Windsor declared, before adding, "Christine Quinn!"

The surprise endorsement momentarily stunned Quinn, who burst into tears. If elected, Quinn, who married her partner Kim Catullo last year, would be the city's first gay mayor.

Windsor followed up her impromptu announcement with an official endorsement in a video circulated by the Quinn campaign.

Quinn "understands the problems of managing a big city like New York. She comes of middle-class background herself and has true compassion for the struggling middle class and the struggling working class and the struggling not-working class today. And you don't find that very often," Windsor says in the video.

Also, Quinn's rival Bill de Blasio announced that he'd received the backing of Howard Dean, the former Vermont governor who ran for president in 2004.

"Bill de Blasio is the progressive fighter New York City needs," Dean, who also served as chairman of the Democratic National Committee, said in a statement. "As a lifelong progressive reformer and grassroots organizer, Bill will take on the elite who profit from the status quo at the expense of working families. From battling the flood of corporate money and corrupt insiders deals that infect our politics to challenging the powerful interests that block common-sense gun violence prevention, Bill has always been a voice for everyday New Yorkers."
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Immigration reform bill passes Senate, moves to skeptical House

Washington, July 11 (Newswire): The Senate passed a sweeping immigration reform bill, after a recently hashed-out compromise on border security helped persuade a total of 14 Republicans to vote for the measure. The bill, which passed 68-32, could face a steep uphill climb in the Republican-controlled House.

The vote brings Congress a step closer to passing its first major immigration reform since the 1986 amnesty bill that legalized more than 3 million immigrants under President Ronald Reagan.

Moments before the vote, Sen. Harry Reid, D-Nev., said on the Senate floor that the "historic legislation recognizes that today's immigrants came for the right reason, the same reason as the generations before them ... the right to live in a land that's free."

Republican Chuck Grassley of Iowa spoke against the measure on the floor, arguing that it does not do enough to increase interior immigration enforcement. "The bill won't ensure that a future Congress isn't back here in 25 years dealing with the very same problems," Grassley said.

The "Gang of Eight," a bipartisan group of senators who drafted the bill, had hoped to get 70 out of 100 senators to vote to pass the bill and send a strong signal to the House that the legislation is bipartisan. The bill fell just two votes short of that goal. Republican Sens. Lamar Alexander, Kelly Ayotte, Jeffrey Chiesa, Susan Collins, Bob Corker, Jeff Flake, Lindsey Graham, Orrin Hatch, Dean Heller, John Hoeven, Mark Kirk, John McCain, Lisa Murkowski and Marco Rubio joined the entire Democratic caucus in voting for the measure.

The reform will implement a mandatory, national employment verification system; allow for more legal immigration of low- and high-skilled workers; beef up border security; and eventually give green cards to most of the nation's 11 million unauthorized immigrants who pass background checks and pay fines.

The bill has moved to the right in the Senate on border security, thanks to an amendment adopted last week that will double the number of Border Patrol officers and increase fencing on the southern border by hundreds of miles before any unauthorized immigrants are offered permanent legal status.

But House members working on their own version of immigration reform told The Hill this is not enough: They would prefer that no unauthorized immigrant be offered even temporary legal status until all the border security measures of the bill are fully implemented. Republican Chief Deputy Whip Peter Roskam told reporters the bill is a "pipe dream" that will never pass the House.

Union leaders representing both Border Patrol and Immigration and Customs Enforcement officers say they oppose the bill, and groups that seek lower immigration levels have tried to rally members to call and write senators asking them to kill the bill. But so far, the critics of the bill have been outnumbered.

Rubio, of Florida, has worked as a conservative ambassador for the legislation. Rubio highlighted his immigrant parents' journey to the United States in a speech on the floor. "Here, in America, generations of unfulfilled dreams will finally come to pass," he said.

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House spent about $2m of taxpayers' money on coffee, pastries

Washington, July 11 (Newswire): Most Americans start their day with at least one cup of coffee, maybe paying $2 to $5, but many might be surprised to know they also treat their members of Congress to some joe and a bagel or two, as well.

The Sunlight Foundation, a watchdog group advocating for government transparency, crunched the numbers for ABC News and found that the House of Representatives spent nearly $2 million on coffee and food in 2012 for events in and around the Capitol.

"Congress is spending an awful lot of money to entertain their members," said Bill Allison, the foundation's editorial director. "[It's] coffee and doughnuts and then some very nice catering places in Washington, D.C., as well."

The money is part of lawmakers' representational allowances, which can be used to pay for everything from sending mail to constituents to entertaining visitors. The foundation did not know who the visitors were.

Although lawmakers were paring back, Allison said, they hadn't changed certain rules when it came to food and drink.

"Catering companies can get as much business from the House as they have in the past," he said.

The Sunlight Foundation found that expensive catering was truly a bipartisan effort, with leaders hosting their own members. Republican House Speaker John Boehner spent $64,000. Democratic House Minority Leader Nancy Pelosi spent $61,000. and No. 2 Democrat Steny Hoyer spent $52,000.

The biggest spender in the House was No. 3 Republican Kevin McCarthy of California. On his Facebook page, pictures of meetings include fruit, bagels, croissants and coffee.

McCarthy's 2012 grand total - $95,000, with an additional $4,000 being spent on bottled water - was enough to pay the salaries of two mid-level staffers on Capitol Hill.

"That's a couple of jobs for the average American," Allison said.

McCarthy declined an ABC News request for an interview.

When ABC News approached him as he walked down a hallway in the Capitol to ask about the nearly $100,000 spent to cater meetings and dinner, he responded: "You noticed. We cut it out."

Actually, what ABC News noticed were the leftovers from a meeting McCarthy had just attended. A staffer even offered a bagel.

While McCarthy said he was making cuts, his office did not provide any numbers.

Allison said Americans should ask their leaders to buy their own coffee and pastries.

"We are in an age of austerity and sequestration and budget cuts," Allison said. "It seems like if you are looking for places to cut, the entertainment budget would be the first one you would go to."
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Consumer spending, jobs data point to lukewarm growth

Washington, July 11 (Newswire): Consumer spending rebounded in May and new applications for unemployment benefits fell last week, suggesting the economy remained on a moderate growth path.

While other data showed contracts to buy previously owned homes approached a 6-1/2 year high in May, the data taken together suggested economic activity would probably remain lukewarm and discourage the Federal Reserve from scaling back its monetary stimulus anytime soon.

"It's still a picture of better growth, but there is little to suggest that we are going to get the kind of break-out growth that would entail a tighter environment from policymakers in the near future," said Brian Levitt, an economist at OppenheimerFunds in New York.

The Fed said last week that downside economic risks had waned and it could start pulling back on the pace of its monthly bond purchases this year.

Consumer spending, which accounts for more than two-thirds of U.S. economic activity, increased 0.3 percent last month, reversing April's 0.3 percent drop, the Commerce Department said.

When adjusted for inflation, spending rose 0.2 percent. However, real spending for April was revised lower to the first contraction in six months, suggesting second-quarter economic growth could come in a bit weaker than economists had expected.

Barclays cut its GDP growth forecast by 0.4 percentage point to a 1.4 percent pace. Goldman Sachs pared its forecast by a tenth of a point to 1.7 percent, while Morgan Stanley trimmed its estimate to 1.5 percent from 1.6 percent.

The economy expanded at a sluggish 1.8 percent rate in the first three months of the year.

In one bright sign, Winnebago Industries Inc reported that its profit nearly doubled in the quarter that ended June 1 as sales of motor homes jumped 55 percent and sales of trailers rose 10 percent.

Separately, the Labor Department said initial claims for unemployment benefits fell 9,000 last week to a seasonally adjusted 346,000. A four-week moving average that irons out week-to-week volatility fell 2,750 to 345,750.

The report signaled little change in the pace of job growth, which has averaged 189,000 jobs per month so far this year.

"It appears that the underlying pace of layoffs remained stable during June. The other half of the employment equation, hiring, also likely held steady," said Guy Berger, an economist at RBS in Stamford, Connecticut.

Stocks on Wall Street rose on the data, putting the broader Standard & Poor's 500 index on track for a third straight day of gains. The dollar gained broadly and prices for U.S. Treasury debt pushed higher.

U.S. stocks and government bonds had sold off in the wake of the Fed's comments last week, and several officials at the central bank have since sought to push against market fears of an imminent stop to their bond buying program. The Fed has been purchasing $85 billion in bonds each month in an effort to keep borrowing costs down and spur stronger growth.

"If labor market conditions and the economy's growth momentum were to be less favorable than in the (Fed's) outlook — and this is what has happened in recent years — I would expect that the asset purchases would continue at a higher pace for longer," New York Federal Reserve Bank President William Dudley said.

A range of recent data, including reports on regional factory activity, business spending plans and consumer confidence, have pointed to an economy that is regaining its footing after stumbling early in the second quarter.

A big part of that stabilization is due to the strengthening housing recovery.

The National Association of Realtors said its Pending Home Sales Index, based on contracts signed in May, increased 6.7 percent to 112.3 - the highest level since December 2006.

While part of the jump in pending sales reflected a rush by buyers to lock in deals before mortgage rates climbed higher, it also signaled underlying strength.

House price gains have helped buoy consumer spending in the face of higher taxes and tepid income growth.

Income, however, grew 0.5 percent last month, the largest gain since February, after nudging up 0.1 percent in April, the Commerce Department report showed. The gain helped lift the saving rate to a five-month high of 3.2 percent.

"That sets up for a little bit of progress in the third quarter," said Bruce McCain, chief investment strategist at Key Private Bank in Cleveland, Ohio.

The report also showed a bit of inflation in the economy, pointing to some pick-up in demand.

A price index for consumer spending inched up 0.1 percent in May after declining two straight months, and a core reading that strips out food and energy costs also rose 0.1 percent after being flat in April.

Over the past 12 months, inflation increased 1 percent, well below the Fed's 2 percent target but up from 0.7 percent in the period through April.

Core prices were up 1.1 percent from a year ago, the same as in April. While that suggested some stabilization after a long period of disinflation, it matched a record low reached only a few times since the series started in 1960.
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Justice Department probing American, US Airways merger

Washington, July 11 (Newswire): The US Justice Department is taking depositions as part of a probe into a planned merger of American Airlines Inc (AAMRQ.PK) and US Airways Group Inc (LCC) that would create the world's largest airline, three sources close to the discussions said.

The sticking point in talks between the Justice Department and the companies is whether the airlines will agree to sell slots, take off and landing rights, to reduce their dominance at Reagan National Airport outside Washington, D.C., according to one source.

The three sources spoke privately to protect business relationships.

US Airways announced on February 14 that it planned to merge with American, which is emerging from bankruptcy, to create an $11 billion airline. The deal requires the approval of the U.S. Justice Department and the Department of Transportation. The companies hope to wrap up the merger by the end of September.

The fact that the Justice Department is taking sworn testimony in the form of depositions indicates it has concerns that the proposed merger creates antitrust problems. Depositions will be needed if the agency approves the deal with conditions or, in rare cases, if it decides to try to stop it. The department could also decide to approve the merger without requiring asset sales.

Depositions preserve testimony if the department decides to challenge the merger, said Robert Doyle, an antitrust expert with Doyle, Barlow and Mazard PLLC.

If the deal is approved, the new airline would have 68 percent of the slots at Reagan National, far more than Delta Air Lines Inc (DAL) with 12 percent, United Airlines (UAL) with 9 percent and the 11 percent held by other airlines, according to a report by the U.S. Government Accountability Office.

The companies have pushed back hard against any suggestion that takeoff and landing slots at Reagan National be sold.

US Airways CEO Doug Parker told lawmakers in congressional testimony last week that requiring the combined company to surrender slots could mean fewer flights to small and medium-sized cities.

Justice Department spokeswoman Gina Talamona said only that the agency's investigation was ongoing.

Antitrust experts have said the Justice Department could request divestitures of some slots at Reagan National and a small number of other airports. Outside these hubs, the carriers fly different routes for the most part.

In late May, more than 100 members of Congress asked U.S. regulators to allow the new American to keep all the slots at Reagan National. The airport is used by many members of Congress to travel to and from their home districts.

The U.S. airline industry has undergone five years of rapid consolidation. Delta acquired Northwest Airlines in 2008, United merged with Continental in 2010 and Southwest Airlines Co (LUV) bought discount rival AirTran in 2011.

With fewer carriers competing, ticket prices have risen. The average fare rose about 8 percent to $375 in the third quarter of 2012, compared with $346 in 2008, according to the U.S. Bureau of Transportation Statistics.
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Cengage Learning may file for bankruptcy protection soon: WSJ

New York, July 11 (Newswire): Textbook publisher Cengage Learning Acquisitions Inc may file for bankruptcy protection in the coming days, the Wall Street Journal said, citing people familiar with the matter.

The publisher, which is owned by British investment firm Apax Partners, is currently negotiating a prearranged bankruptcy restructuring with senior creditors and plans to seek Chapter 11 court protection as early as July 5, the Journal said.

Cengage has struggled in recent times as customers shift more to Internet study materials on smartphones and tablets and state and local governments reduce spending on school books.

The Stamford, Connecticut-based publisher is discussing a host of options with creditors to eliminate a significant chunk of debt, according to the Journal. They include forgiving debt for ownership stakes in a restructured Cengage; exchanging current debt for new debt with a later due date; and receiving some cash repayment.

Creditors, which include Apollo Global Management LLC (APO), BlackRock Inc (BLK), Oaktree Capital Management and KKR Asset Management, part of KKR & Co LP (KKR), hold more than $4 billion in debt, the financial daily said.

In March, the publisher hired restructuring advisers and drew down a revolving credit facility of $430 million to ensure that its businesses have the cash they need.

Cengage had warned that if it was unable to refinance or extend its 2014 loan it may not have sufficient liquidity to finance its operations.

Formerly known as Thomson Learning, Cengage was acquired by Apax and Omers Capital Partners in 2007 in a $7.75 billion leveraged buyout from Thomson Corp.
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CFTC charges Corzine in MF Global collapse

Washington, July 11 (Newswire): A top US regulator charged former MF Global chief Jon Corzine over the collapse of the futures brokerage, blaming the former Goldman Sachs co-chief executive with being a key actor in one of the country's 10 biggest bankruptcies.

The Commodity Futures Trading Commission said it will seek in a civil case to ban Corzine and former Assistant Treasurer Edith O'Brien from the industry, and also seek penalties against the two.

"Mr. Corzine is charged with being more than a passive actor in the downfall of MF Global," CFTC enforcement head David Meister said on a call with journalists. "He lacked good faith and ... violated his supervision obligations."

The CFTC also settled with MF Global Inc, which agreed to pay a $100 million penalty and funds still owed to customers, but will continue to pursue MF Global Holdings Ltd.

The futures brokerage collapsed in October 2011 under the weight of aggressive bets on European sovereign debt, after Corzine - a former New Jersey governor and U.S. senator - sought to transform the brokerage into a global investment bank.

But investors quickly lost confidence in the company's health when the European economy weakened in the middle of 2011, asking MF Global to put up more money to secure the trades, and causing its remaining cash to rapidly vanish.

Customers were left reeling after it was discovered that about $1.6 billion was missing from their accounts and that the company had used the money to stop gaps in its business, which unlawful and caused a political fire storm.

"This is an unprecedented lawsuit based on meritless allegations," said Andrew Levander, a lawyer for Corzine. "Mr. Corzine did nothing wrong, and we look forward to vindicating him in court," he said.

O'Brien's lawyer had no immediate comment.

In its investigations, the CFTC found that MF Global's company treasurer was describing the liquidity situation as "skating on the edge" and recommended to "take the keys away" from Corzine, which did not happen.

Corzine has often struck a defiant tone when testifying in late 2011 before lawmakers about the debacle, pointing the finger at back-office dealings he had no insight in, and denying knowledge of any instructions to misuse customer funds.

And O'Brien invoked her constitutional right against self-incriminated and refused to answer questions when called to testify. But the CFTC's complaint places the two firmly at the heart of the $41 billion bankruptcy.

In the last week the company existed, Corzine was aware of its true low cash balance, but he continued to pay large obligations, the CFTC said in its complaint.

"Our investigation also recovered an audio recording of (O'Brien) saying to a colleague that it could be 'game over' from a regulatory perspective if the customer funds weren't returned," Meister said on the call.

"Given what (the CFTC) must have perceived to be the challenges of the facts I think they've crafted a complaint that lays out a good theory," said Gary DeWaal, who formerly worked as a senior trial attorney for the agency. "From a drafting perspective, the complaint tells a complete story," he said.

But another lawyer, asking to speak anonymously, said there was little in the complaint that pointed to fraud, reducing chances of any criminal charges.

But U.S. Representative Michael Grimm, a New York Republican, urged prosecutors to bring criminal charges against Corzine, saying there was growing proof that he had committed perjury in his testimony before lawmakers.

The CFTC also sought an order for Corzine and O'Brien to disgorge any salaries or bonuses, or trading profits, that they had received from any unlawful actions.

Louis Freeh, the trustee liquidating MF Global, has said in the past he believed customers would get all their money back when the company in April won court approval to liquidate its assets, and end its $40 billion bankruptcy.

Most customers have already been reimbursed for about 93 percent of the value of their accounts.

There was praise from across the political spectrum for the CFTC's action. Senator Debbie Stabenow, a Michigan Democrat, and Texas Republican Congressman Randy Neugebauer cited the importance of futures markets for farmers, who use them to protect against wild swings in commodity prices.

But not everybody was happy.

"I don't think the penalty is high enough," said Dean Tofteland, a Minnesota farmer, who is still missing about $20,000 he had at MF Global when it collapsed.

"Apparently there's still this mindset out there that people can get away with stuff like this if you're well connected like Jon Corzine is," he said.
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Analysis: In shadow of landmark decisions, U.S. high court also rules for business

Washington, July 11 (Newswire): Less noticed in a flurry of high-profile rulings on race, voting rights and gay marriage was how the U.S. Supreme Court rounded off its term by delivering a string of victories to businesses and employers.

Just this week, the court handed wins to generic drug manufacturers facing design-defect lawsuits, employers battling harassment and retaliation claims and landowners struggling to obtain permits for construction projects. In all four cases, the court was split 5-4 with the conservatives in the majority.

Overall, during the term that started nine months ago, the Supreme Court has delivered a series of victories for corporate defendants on class action lawsuits and arbitration, curbing the ability of consumers to file mass claims against companies over such matters as defective products and unfair practices. Comcast Corp (CMCSA) and American Express Co (AXP) were among the big winners in those cases.

As progressive groups have been quick to point out, the U.S. Chamber of Commerce, the main group representing business interests, received a favorable outcome in 14 of the 18 cases in which it filed friend-of-the-court briefs.

The court's business rulings represent "troubling trends that reach back a decade or more, with the court's conservative majority making it harder for consumers, workers and small businesses to go to federal court and hold large corporations accountable," said Doug Kendall, president of the Constitutional Accountability Center, a progressive legal group.

Kate Comerford Todd, chief counsel for appellate litigation at the Chamber's litigation arm, brushed aside suggestions that the court - led since 2005 by Chief Justice John Roberts, an appointee of Republican President George W. Bush - was overly friendly to business.

Citing a popular view within the business community, she said the court was merely reining in the plaintiffs' lawyers who can make millions of dollars in a single case representing multiple plaintiffs in suits against corporate defendants.

"We see a court that has in recent years beaten back the plaintiffs' bar's aggressive campaign to contort the rules and law to serve their purposes," she said.

As is normal for the court in its final week, it issued rulings in some of its most divided cases.

It issued two rulings that limited the ability of employees to make harassment or retaliation claims against employers under Title VII of the 1964 Civil Rights Act.

The court ruled against an African-American Ball State University catering assistant who claimed she was harassed on the basis of race and a University of Texas doctor of Middle Eastern descent who claimed he lost his job in retaliation for complaining of bias.

The rulings prompted liberal Justice Ruth Bader Ginsburg to call out the majority in a statement from the bench, saying they had "corralled" Title VII.

The Chamber of Commerce filed briefs in both cases in support of the employer. Todd said the rulings simply set clearer rules for employers and employees alike.

"The court's Title VII cases this week provide much needed clarity," she added.

On the same day as the employment decisions, the court also issued its ruling on whether generic drug makers could be sued under state law for design defects in medications that already have been approved by the U.S. Food and Drug Administration.

Justice Samuel Alito wrote on behalf of the majority that although the case "arises out of tragic circumstances," the lawsuit was blocked as a result of the FDA's approval of the drug and the warnings that accompanied its sale. The ruling was a "straightforward application" of federal law, he said.

Perhaps the least-noticed, most significant case - and thus branded by some as the term's biggest "sleeper" - was the ruling on land-use permit applications.

Ruling in favor of a Florida landowner, Coy Koontz, the court expanded the ability of property owners to challenge permit conditions imposed upon them by government land-use agencies.

Under Supreme Court precedent, government agencies have always had to provide a justification to impose conditions, but the court expanded the limitations on such requests by saying that legal review can be triggered even if officials deny a permit application and in instances in which the only condition is a money payment.

Alito again wrote for the majority, making note of the "special vulnerability of land-use permit applicants to extortionate demands for money" from government agencies.

Close observers of land-use law say the decision could limit the ability of government entities to require developers to pay for the environmental impact of a project.

Jonathan Adler, a professor at Case Western Reserve University School of Law, said the ruling requires regulators "to justify the burdens they would impose," which he believes encourages accountability.

The Chamber of Commerce filed briefs in the permit application case in support of the property owner and the generic drug case in favor of the drug maker.

Scott Nelson, a lawyer with the consumer advocacy group Public Citizen, said he was wary of attributing too much to the chamber's winning record.

"It's not a situation where there's a majority that sits down and looks to see if the Chamber of Commerce files a brief and this is the way we should vote," he said.
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Japan business mood seen turning positive: BOJ tankan

Tokyo, July 11 (Newswire): Japanese manufacturers' sentiment turned positive in the three months to June for the first time in nearly two years, a closely-watched central bank survey is likely to show in a sign recent market turbulence has yet to hurt the feel-good mood created by the government's reflationary policies.

The Bank of Japan's "tankan" survey will likely show the headline index for big manufacturers' sentiment improved 11 points from three months ago to plus 3, according to a poll.

That would be the second straight quarter of improvement and the first positive reading - which means optimists outnumbered pessimists - since the survey of September 2011, and vindication of Prime Minister Shinzo Abe's "Abenomics" policy of aggressive monetary stimulus and fiscal spending.

Service-sector sentiment also likely brightened as consumers spent more, with the index for big non-manufacturing companies likely to have risen 5 points to plus 11, the poll showed.

A positive reading will bode well for the central bank, keen to end grinding deflation that has haunted Japan for 15 years and achieve its 2 percent inflation target in roughly two years through aggressive monetary stimulus.

"You cannot deny that the economy is improving, and that domestic demand is leading the way," said Hiroshi Miyazaki, senior economist at Mitsubishi UFJ Morgan Stanley Securities in Tokyo.

"Government stimulus spending is contributing to growth and the services sector is gaining strength. The BOJ's monetary easing is becoming more effective, so there's no need for additional measures."

The upbeat survey was compiled amid the market turmoil that drove up bond yields and wiped out gains in Tokyo shares made on hopes for Abe's stimulus plans. It should reinforce views the world's third-largest economy is steadily recovering, analysts say.

Big manufacturers and non-manufacturers both expect business conditions to improve further three months ahead, a sign they see the negative effect of the recent market turbulence on the economy as limited at least for now, the poll showed.

Positive market sentiment turned around in late May when the BOJ's huge asset purchases disrupted the bond market and drove up yields which, coupled with expectations of the U.S. Federal Reserve's tapering of monetary stimulus, hit global stocks and triggered a rebound in the safe-haven yen.

Still, the tankan report, a key touchstone for BOJ policymakers, will likely reinforce the view that Japan's economy remains on track for a steady recovery backed by a pickup in exports and private consumption.

The tankan's sentiment indexes are derived by subtracting the percentage of respondents who say conditions are poor from those who say they are good.

Big firms are likely to increase capital expenditure by 2.9 percent in the current business year from April, the poll showed, a sign the positive mood may be prompting them to expand business operations.
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150 fall ill after consuming ‘Wazwan’

Kachwa Muqam, July 11 (Newswire): More than 150 people have fallen ill after consuming Wazwan at a marriage party in this village in held Kashmir's Baramulla district.

 Reports said the villagers complained of vomiting and dysentery soon after they consumed the feast at the marriage party.

 "All the people who had consumed the food fell sick," locals said.
 According to locals, they were immediately referred to nearby hospitals including Primary Health Centre Kalantara, Sub District Hospital Chandoosa and Sub District Hospital Kreeri.

 "People who consumed the Wazwaan complained of vomiting and dysentery soon after they finished the meals. We treated more than 75 patients here," said Dr. Bilal posted at PHC Kalantara.

 Talking to Greater Kashmir BMO Kreeri Dr. Bilkees Shah admitted that the people have fallen sick due to food poisoning.

 "We received more than 130 patients who complained of vomiting, diarrhea and dysentery. We treated 65 patients at the PHC Kalantara, 25 at  Sub Centre  Kachwa Muqam and more than 40 patients at SDH Kreeri," she said. She said a team was sent to collect food samples from the village.

 "We sent a team comprising Health educators to collect food samples from the village but those who had cooked the Wazwaan have not provided the samples to the team," she said.
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No lessons learned from Kokernag tragedy!

Srinagar, July 11 (Newswire): Eight students and five teachers of a private school were injured after the school bus they were travelling in for picnic to Pahalgam turned turtle here.

 Reports said the school bus of Green Valley Public High School here overturned on the Foreshore Road, with students of Class 10th on board. They were on way to the famed tourist destination, Pahalgam, in held Kashmir.

"The bus overturned on the Foreshore Road after it failed to negotiate a curve," witnesses said. "Eight students and five teachers suffered injuries in the accident."

 Witnesses said, "Four students Huziaf Tariq, Shakir Rasool, Iram Jan and Saima Mushtaq suffered serious injuries."There were 22 passengers on board.

 The injured were rushed to SK Institute of Medical Sciences here where there condition is stated to be stable.

 "All the injured students are stable. Five of them have been discharged from the hospital," said a medico at SKIMS.

 Meanwhile, Director School Education Kashmir Mir Tariq visited the injured and announced financial help for their treatment on behalf of the Education Minister.

 He said the government has announced Rs 2000 for those who received minor injuries and Rs 5000 for those with major injuries."Director School Education also spoke to Chief Education Officer Ganderbal on phone and informed him about the instructions issued by Minister for Education to conduct an inquiry into the incident and furnish a report so that necessary measures are taken to avoid such accidents in future," said an official.

 Pertinently, nine school children were killed and eight others injured, six among them seriously, when a school bus met with an accident in Kokernag area of Islamabad (Anantnag) in held Kashmir in April this year.

The accident and the resultant deaths of school children sent shock waves across Kashmir even as all the mainstream and separatist leaders expressed grief over the loss of young lives.
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Neelum valley was home to a vibrant civilization: Study

Muzaffarabad, July 11 (Newswire): The picturesque Neelum valley in Azad Kashmir was home to a vibrant civilization in ancient times, latest exploration and documentation of some archeological sites of the area has revealed.

The exploration and documentation of these sites was initiated by Rukhsana Saeed, a PhD scholar from the Quaid-e-Azam University's Taxila Institute of Asian Civilizations (TIAC) under the supervision of renowned archaeologist Prof Dr Muhammad Ashraf Khan in October last year.

"The latest detailed survey was conducted in the second week of June, during which some important new sites were discovered and documented in the Neelum valley," Rukhsana told Greater Kashmir.

She said due to its geographical location on the crossroads of Silk Road and its connecting routes, Neelum valley attracted pilgrims, monks and travelers from as far as Korea in the east, Bengal in the southeast and Tibet and Central Asia in the northwest.

She claimed the Valley used to be a great religious hub and syncretism, which was evident from the inscription on steep semi-vertical rocks on extreme borders of the valley which she had documented during the survey.

The inscriptions are under the consideration of linguists for further study and deciphering, Rukhsana said, adding there were some ancient sacred sites of pilgrims from certain periods as well, which had also been documented by TIAC.

According to her, the details of dresses and accessories of figures on rock slabs showed that the Valley had strong cross-cultural links with other civilizations of the area. This was concluded from the figurines on the commemorative stones found in the Valley, she said.

Rukhsana said that some of the coins found from area of study had been identified as from the seventh century AD while some others had not yet been deciphered.

Some of the artifacts were found from the places which were mentioned in ancient texts as sacred, such as Sish Pari, towards the left bank of river Neelum in extreme east, she said. These artifacts were found by locals and presented to research team for documentation, although these are small in numbers but had great archaeological value, she added.

Rukhsana also shared some pictures of these sites with Greater Kashmir but declined to identify the exact places where these were discovered, saying it was for the sake of their protection and preservation. She said such sites were always endangered, as unscrupulous elements would resort to illegal digging and illicit trafficking of artifacts found there.

She said TIAC was preparing for excavation and a trail trench would be started around Sharda, in the upper belt of Neelum Valley, in the first week of July. Rukhsana said she was going to present a paper on new archeological discoveries in PaK at an international conference in Colombo in August, this year.
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Honey bee venom may help design new treatments to alleviate muscular dystrophy, depression and dementia

Islamabad, July 11 (Newswire): Scientists researching a toxin extracted from the venom of the honey bee have used this to inform the design of new treatments to alleviate the symptoms of conditions such as muscular dystrophy, depression and dementia.

Apamin, a natural peptide toxin found in bee venom, is known for its ability to block a type of ion channel that enables a high-speed and selective flow of potassium ions out of nerves.

The blocking of these channels in brain causes nerves to become hyperexcitable, producing improved learning that has implications for the treatment of dementia and depression. In addition, injection of apamin improves the symptoms experienced by sufferers of myotonic muscular dystrophy (MD).

Until now, the exact mechanism by which apamin acts was poorly understood. In a study published in the Journal of Biological Chemistry, two teams from the University of Bristol and the University of Liege in Belgium describe the results of their joint work on these KCa2 potassium ion channels, also called SK channels.

Using computer models and a genetic approach, the researchers were able to pinpoint exactly where apamin binds to block the channel.

To block ion channels, most molecules act as a plug at their external mouth. Perhaps surprisingly, the researchers have discovered that apamin binds away from the channel pore, and causes the shape of the channel to change through an 'allosteric' mechanism, resulting in block

This discovery could accelerate research into the design of new SK channel blockers which could imitate the action of apamin, to target SK channels in neural and muscular conditions such as dementia, depression or MD.

Professor Neil Marrion, from the University of Bristol's Physiology & Pharmacology department, said: "Drug design depends on knowing the target. Our findings have provided a new approach to designing a therapeutic agent that could help with the treatment of a number of conditions."

Professor Vincent Seutin, from the GIGA Neurosciences at the University of Liège, commented on the study: "I am very enthusiastic about the results of our study and I believe that, with the help of this piece of information, the targeting of these channels for the development of future drugs has been made easier."
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Antibody may help treat and prevent influenza outbreaks

Islamabad, July 11 (Newswire): Researchers have discovered a monoclonal antibody that is effective against "Avian" H5N1, seasonal H1N1 and the 2009 "Swine" H1N1 influenza.

Scientists at Sea Lane Biotechnologies, LLC, in collaboration with Mt. Sinai School of Medicine, St. Jude Research Hospital and the Scripps Research Institute, have shown that this antibody potently prevents and treats the Swine H1N1 influenza in mouse models of the disease.

Previous work on this antibody, A06, demonstrated "first in class" activity against the evolutionarily distant Avian H5N1 and seasonal H1N1 influenzas.

The authors believe that the antibody targets a conserved region of the viral coat protein, hemagluttinin, accounting for the extended breadth of activity against multiple, genetically distinct strains.

In this study, the authors isolated A06 from a combinatorial library derived from a survivor of highly pathogenic H5N1 infection. They demonstrate that the antibody is effective against 2009 pandemic influenza in a cell culture assay and also in mouse models of disease when given before and after lethal influenza infection.

In late 2009, the WHO declared the first influenza pandemic in 40 years due to the 2009 "Swine" H1N1 influenza virus which swept the globe. Fortunately, the Swine influenza proved to be mild. The pandemic did, however, point out the weaknesses in the current treatment options available to stop a more virulent pandemic. Vaccines take months to prepare and many strains of influenza are already resistant to small molecule treatments like Tamiflu. Antibodies, like A06, could provide a significant line of defense against a more serious pandemic threat and contribute to efforts to create a universal vaccine.

This study demonstrates the therapeutic potential of monoclonal antibodies to protect and treat influenza. While the study was limited to mice, the activity is reflective of the potential benefit to humans. Anti-influenza antibody therapeutics could help to fill the current gap in the existing arsenal of treatments against influenza and could, one day, help to contain a deadly pandemic, according to the authors.
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Chemical engineers discover an enhanced delivery method of DNA payloads into cells

Islamabad, July 11 (Newswire): Chang Lu and his chemical engineering research group at Virginia Tech have discovered how to "greatly enhance" the delivery of DNA payloads into cells.

Lu's ultimate goal is to apply this technique to create genetically modified cells for cancer immunotherapy, stem cell therapy and tissue regeneration.

One of the most widely used physical methods to deliver genes into cells "is incredibly inefficient because only a small fraction of a cell's total membrane surface can be permeated," said Lu, an associate professor of chemical engineering at Virginia Tech.

The method Lu is referring to is called electroporation, a phenomenon known for decades that increases the permeability of a cell by applying an electric field to generate tiny pores in the membrane of cells.

Lu called the process "a new spin on DNA delivery." He explained the process saying, "Conventional electroporation methods deliver DNA only within a very small portion of the cell surface, determined by the physics governing the interaction between an electric field and a cell. Our method enables uniform DNA delivery over the entire cell surface, which is the first time we are aware that this has been demonstrated. The result is a greatly enhanced transfer of the genetic material."

Lu said his new approach harnesses "hydrodynamic effects that uniquely occur when fluids flow along curved paths. Flow under these conditions is known to generate vortices. Cells carried by such flow experience rotation and spinning that help expose the majority area of its surface to the electric field. " Having the gene delivery done by flows in curved paths is key in the gene delivery as opposed to the traditionally used, electroporation in static solution or in straight channels. "A spiral-shaped channel design yields a two-fold increase than a straight channel and an even larger factor compared to in static solution," he added.

By using fluorescence microscopy, they were able to "map" the area on the cell surface that was subjected to electroporation, and determine the extent of the DNA entry into the cell.

Lu explained the conventional delivery using a cuvette-type of device with static cell suspension produces DNA delivery confined to a narrow zone on the cell surface.

However, when electroporation is applied to flowing cells in a spiral or curved channel , the images "appear dramatically different with the DNA delivery uniformly distributed over the entire cell surface."

Lead author of the paper is a former graduate student from Lu's group, Jun Wang. Another graduate student, Yihong Zhan, and Victor Ugaz, a professor of chemical engineering atTexas A&M University coauthored the paper, together with Lu. The National Science Foundation, the U.S. Department of Agriculture, and the Wallace Coulter Foundation have supported this research.

Lu, a 2007 Wallace Coulter Foundation and 2008 National Science Foundation young investigator award recipient, moved from Purdue University to Virginia Tech at the end of 2009. His group plans to make larger devices taking advantage of this phenomenon and apply them to large volume gene delivery in the near future.
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