Year on, Siraj Bazar awaits road repairs

Thursday, 23 May 2013

Srinagar,: The residents of Siraj Bazar, Zaina Kadal and its adjoining areas in Shaher-e-Khaas are up in arms against the authorities for failing to macadamize the road in the area, post excavation.

A delegation from the area told Greater Kashmir that “Nearly a year ago the roads were excavated for laying of water pipes coming in the way of renovated Zaina Kadal bridge. Since then, the department has failed to macadamize the vital link road of Siraj Bazar connecting with Zaina Kadal and Maharaj Gunj,” the locals said.

 “The road is full of potholes and there is every possibility of anyone slipping on it... We have been facing lots of hardships walking on the dilapidated roads,” the inhabitants complained.

 They said while rains leave the potholes inundated, sunshine triggers billows of dust. “Several people are suffering from the chest related disorders due to the dust,” said the residents.
 When contacted an R&B official said the matter would be looked into.

Meanwhile the locals have appealed District Development Commissioner, Er Farooq Ahmed Shah to look into the matter and get the road repaired.

 “In the wake of recent constitution of a Task Force to look into timely road repairs, the administration must take a serious note of the issue,” the residents said.

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No sponge in human family tree: sponges descended from unique ancestor

Islamabad, : Since the days of Charles Darwin, researchers are interested in reconstructing the "Tree of Life", and in understanding the development of animal and plant species during their evolutionary history. 

In the case of vertebrates, this research has already come quite a long way. But there is still much debate about the relationships between the animal groups that made their apparation very early in evolutionary history, probably in the late Precambrian, some 650 to 540 million years ago.

An international research group led by LMU Munich Geobiology Professor Gert Wörheide and colleagues from France and Canada has now managed to explain the relationships between some of these very early animal groups with a high degree of confidence. In the most comprehensive study of its kind, the researchers show that all sponges descended from a unique sponge ancestor, who in turn was not the ancestor of all other animals. That means that humans did not descend from a sponge-like organism either, as some scientists have put forward. Moreover, the results also suggest that the nervous system only evolved once in animal history.

The most ancient animal groups (phyla) include the Porifera (sponges), Placozoa, Cnidaria, and Ctenophora (comb jellies). The sponges are extremely simply built, and have no organs. The placozoans also have a very simple structure. They have a flat, disk-shaped body, and no organs either. Comb jellies, the ctenophores, are life forms that resemble jellyfish. The true jellyfish, however, are part of the cnidarians, a phylum that also includes corals and sea anemones. The exact relationships among these early animal groups are still controversial, as different research groups have often obtained conflicting results. In particular, results from morphological studies, which look for structural similarities between different organisms, frequently contradict the results from molecular biological studies. The latter explore the functions of genes, and deduce phylogenetic relationships from gene sequences.

Aiming to resolve these controversies, a group of international scientists led by Hervé Philippe (Université de Montréal, Canada), Gert Wörheide (LMU Munich, Germany) and Michael Manuel (University of Paris, France) performed the most comprehensive study to date and investigated 128 genes from a total of 55 species – including nine poriferans, eight cnidarians, three ctenophores and the single known species of placozoans. Their analyses were based on a relatively new approach called phylogenomics, which determines the evolutionary relationships of life forms by comparing large datasets of gene sequences. Together with biochemists, evolutionary and computational biologists from Germany, France and Canada, the team analyzed more than 30,000 amino acid positions. Using computer analyses, the researchers then estimated a phylogenetic tree that displays how related the studied animals are.

One of the most significant outcomes of this study is new evidence that all species of sponges are descendants of a single ancestor. On the other hand, Bilateria, which include worms, mollusks, insects, and vertebrates, did not descend directly from this "spongy" ancestor. "If the ancestral animal would have had a sponge-like organization or body, as some earlier molecular studies repeatedly claimed, then we would all be descendents of such sponge-like organisms," explains Wörheide. "This proposition generated a lot of attention in the past. But our results clearly disagree with it." The analyses also revealed that ctenophores and cnidarians most likely belong to a common group. "This group, the "coelenterates", is most closely related to the bilaterians," explains Wörheide. "Our results support, after much controversy, a hypothesis that was already formulated back in 1848."

The investigation also provides new insights into the development of individual organ systems. "Both coelenterates and bilaterians already have nerve cells. Their now corroborated close relationship also suggests that the nervous system developed only once in animal history," Wörheide states. And yet, another recent and less comprehensive study concerning the non-bilaterians proposed the unorthodox hypothesis that the comb jellies had already diverged from all other species even before the sponges. "Since the comb jellies already have nerve and muscle cells, this would suggest that these features developed several times independently in animal history, or that they were lost in sponges and placozoans," explains the LMU researcher.

This new study, which compared more evolutionarily ancient life forms than ever before, presents a stimulating framework for future studies. "Our results can now be used to explore how certain key features evolved among animals," says Wörheide. There is evidence, for example, that part of the genetic toolkit responsible for building the nervous system in other animals was already present in sponges. Similarly, eye-like sensory organs can already be detected in box jellyfish. "One of the goals of future studies will now be to find out how and when the genetic toolkit for the nervous system, muscles and sensory organs evolved in animal history," Wörheide concludes.

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Movement without muscles: zoologists on trail of evolution of body contractions

Islamabad,: All animals move -- cheetahs faster, snails more slowly. Muscle contractions are the basis of movement in many, but not all, species. Some animal groups don't have any muscles at all, as they branched off from the evolutionary path before muscle cells evolved. 

Yet these animal groups -- for instance, the sea sponges -- are not incapable of movement. Sponges are able to contract without muscles. But which cells in sponges are actually contracting?

A group of scientists headed by associate professor Dr. Michael Nickel of Friedrich Schiller University Jena (Germany) is looking into movement without muscles. The scientists from the Institute of Systematic Zoology and Evolutionary Biology are especially interested in the question of which evolutionary forerunners did muscle cells derive from.

In a new study published in the Journal of Experimental Biology, the evolutionary biologists are offering new answers to this question. In their paper, the researchers described how they generated three-dimensional (3-D) images, with the help of synchrotron radiation-based X-ray microtomography. Using this technique, the Jena scientists, in co-operation with the Helmholtz-Zentrum Gesthacht at the Deutsches Elektronen Synchrotron Hamburg, were able to compare and visualize the 3-D structure of contracted and expanded sponges.

"A key feature of our approach is the use of 3-D data for measuring the volume and surface of our sponges," says Nickel. "Although the 3-D volumetric analysis is widely known and used in the technical sciences, it has rarely been used in zoology -- in spite of its enormous information potential."

Nickel's team was able to show that the inner and outer surfaces -- and therefore the epithelial cells, so-called pinacozytes -- cause the strong body contractions of the sponges. Ultimately, the Jena scientists believe they have also settled a hundred-year-old debate about the cause of cellular contractions. Until recently, spindle-shaped cells in the tissue of sponges as well as epithelial cells were thought to be possible candidates. But now, the Jena scientists have been able to identify the true initiator of the contractions.

These findings offer new approaches to understanding the evolutionary development of musculature. "The early evolution of muscles has not been fully understood so far. According to current scientific knowledge, muscle cells seem to have surfaced from nowhere," Nickel says. "But surely there must have been evolutionary predecessor systems, that have been unknown until now." The sponge epithelial cells are now moving to the forefront in the evolutionary biologists' continuing research in this field. "There is a lot of evidence that the sponge epithelial cells and the muscle cells of all the other animals are going back to a common contractile cellular predecessor." In future, scientists hope to test this hypothesis using genome and gene expression-related data.

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Human brain's most ubiquitous cell cultivated in lab dish

Islamabad, : Pity the lowly astrocyte, the most common cell in the human nervous system. Long considered to be little more than putty in the brain and spinal cord, the star-shaped astrocyte has found new respect among neuroscientists who have begun to recognize its many functions in the brain, not to mention its role in a range of disorders of the central nervous system.

Now, writing in the journal Nature Biotechnology, a group led by University of Wisconsin-Madison stem cell researcher Su-Chun Zhang reports it has been able to direct embryonic and induced human stem cells to become astrocytes in the lab dish.

The ability to make large, uniform batches of astrocytes, explains Zhang, opens a new avenue to more fully understanding the functional roles of the brain's most commonplace cell, as well as its involvement in a host of central nervous system disorders ranging from headaches to dementia. What's more, the ability to culture the cells gives researchers a powerful tool to devise new therapies and drugs for neurological disorders.

"Not a lot of attention has been paid to these cells because human astrocytes have been hard to get," says Zhang, a researcher at UW-Madison's Waisman Center and a professor of neuroscience in the UW-Madison School of Medicine and Public Health. "But we can make billions or trillions of them from a single stem cell."

Although astrocytes have gotten short shrift from science compared to neurons, the large filamentous cells that process and transmit information, scientists are turning their attention to the more common cells as their roles in the brain become better understood. There are a variety of astrocyte cell types and they perform such basic housekeeping tasks as helping to regulate blood flow, soaking up excess chemicals produced by interacting neurons and controlling the blood-brain barrier, a protective filter that keeps dangerous molecules from entering the brain.

Astrocytes, some studies suggest, may even play a role in human intelligence given that their volume is much greater in the human brain than any other species of animal.

"Without the astrocyte, neurons can't function," Zhang notes. "Astrocytes wrap around nerve cells to protect them and keep them healthy. They participate in virtually every function or disorder of the brain."

The ability to forge astrocytes in the lab has several potential practical outcomes, according to Zhang. They could be used as screens to identify new drugs for treating diseases of the brain, they can be used to model disease in the lab dish and, in the more distant future, it may be possible to transplant the cells to treat a variety of neurological conditions, including brain trauma, Parkinson's disease and spinal cord injury. It is possible that astrocytes prepared for clinical use could be among the first cells transplanted to intervene in a neurological condition as the motor neurons affected by the fatal amyotrophic lateral sclerosis, also known as Lou Gehrig's disease, are swathed in astrocytes.

"With an injury or neurological condition, neurons in the brain have to work harder, and doing so they make more neurotransmitters," chemicals that in excess can be toxic to other cells in the brain, Zhang says.

"One idea is that it may be possible to rescue motor neurons by putting normal, healthy astrocytes in the brain," according to Zhang. "These cells are really useful as a therapeutic target."

The technology developed by the Wisconsin group lays a foundation to make all the different species of astrocytes. What's more, it is possible to genetically engineer them to mimic disease so that previously inaccessible neurological conditions can be studied in the lab.

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Security threats increase against education

Kabul,: Afghan Deputy Minister of Education at a press conference in Kabul warned that threats from armed opposition against education of the country have increased.

He added that in the past five years education of the country has been faced with major challenges, and the threats have increased.

According to the Ministry of Education, at the moment 4600 schools are closed in Afghanistan, 13 schools have been burnt and the presence of girls has decreased in schools compared with last year.

In the last three year approximately 2700 students have been poisoned in different events throughout Afghanistan but ministry of education says that the reason for the poisoning incidents are not clear.

Deputy Minister of Education talked regarding challenges ahead of education system in the country and said that since 2008 armed opposition attacks have significantly increased against the education system of the country and added that more than 8000 schools don’t have buildings and still majority of the schools need reconstruction.

“In the last four year, schools have been attacked by the Taliban. Previously there was no attack on schools, I mean since 2006,” Deputy Minister of Education Asef Nang said.

Meanwhile, Minister of Education signed a work contract of

75 million dollar with Japan and on the other hand Ministry of Education calls land mafia as a great challenge ahead of implementing of this programme.

“With this contract, we will construct 75 schools with the financial support of Japan, with financial management of UNSEF and observation of the Afghan government,” Minister of Education Ghulam Farooq Wardak said.

Deputy minister of education says that this year it was expected to enroll 1.5 million students to the schools but due to lack of capacity and lack of buildings a low number of students have been enrolled.

He says that lack of school books has harmed educational system in the country.

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Afghanistan faces growing unemployment

Kabul, : The Afghan Ministry of Economy said that half of a million of labour force enters Afghanistan’s markets annually without finding employment.

The ministry of economy said that short term projects have been invested during the last 11 years in Afghanistan, and the country now faces growing unemployment.

The comments come as the Ministry of Economy, Ministry of Labour and Social Affairs with cooperation of International Labour Organisation (ILO) and the World Bank in Constant Employment in Afghanistan studied the possible employment opportunities in the country.

According to the investigations, Afghan Economy Minister Abdul Hadi Arghandiwal said that Afghanistan’s 48% labour force is completely unemployed or they have seasonal jobs. The number is growing daily.

“We welcome international community’s aid in the last 11 years. We wish that the aid were invested based on our national needs. Most of the projects were short term to be soon finished or to satisfy donor countries about the projects. The projects were not implemented effectively which caused us to face unemployment.” Abdul Hadi Arghandiwal said.

Meanwhile, the World Bank officials stressed on creating lasting job opportunities in Afghanistan.

“These are vitally important if the private sector can be an active partner in creating the jobs that are needed over the next several decades to come. The World Bank through the international finance cooperation is working with government ministries to deal with both construction and trade licence so that it can help the private sector to be more active in the areas of construction and trading,” said Illango Patchamuthu, World Bank Acting Country Director for Afghanistan.

The ministry said that fears from 2010 made main problems in Afghanistan and caused volatility of investments in the country.

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Woman accused of slapping deputy so she’d go to jail and quit smoking

New York, : A woman allegedly slapped a Sacramento County deputy in order to get arrested. Why? So she would go to jail and be forced to give up smoking cigarettes.

CBS-Sacramento reports that Deputy Matt Campoy was leaving his shift when he felt a slap across his face.

"It was totally unprovoked," said Campoy. "She stepped into me and slapped me in the face."

Etta Lopez, 31, was arrested immediately, according to CBS-Sacramento. The station reports that Lopez sat in front of the jail for hours before allegedly slapping Campoy.

“She told us that she needed to quit smoking,” Campoy told CBS-Sacramento. "She explained it with great detail as to why.”

Lopez is being held in Sacramento County Jail on assault charges. And, yes, the jail is smoke-free, according to CBS-Sacramento.

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Woman accused of slapping deputy so she’d go to jail and quit smoking

New York, : A woman allegedly slapped a Sacramento County deputy in order to get arrested. Why? So she would go to jail and be forced to give up smoking cigarettes.

CBS-Sacramento reports that Deputy Matt Campoy was leaving his shift when he felt a slap across his face.

"It was totally unprovoked," said Campoy. "She stepped into me and slapped me in the face."

Etta Lopez, 31, was arrested immediately, according to CBS-Sacramento. The station reports that Lopez sat in front of the jail for hours before allegedly slapping Campoy.

“She told us that she needed to quit smoking,” Campoy told CBS-Sacramento. "She explained it with great detail as to why.”

Lopez is being held in Sacramento County Jail on assault charges. And, yes, the jail is smoke-free, according to CBS-Sacramento.

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Huge cyber bank theft spans 27 countries

New York, : In one of the biggest ever bank heists, a global cyber crime ring stole $45 million from two Middle Eastern banks by hacking into credit card processing firms and withdrawing money from ATMs in 27 countries, U.S. prosecutors said.

The U.S. Justice Department accused eight men of allegedly forming the New York-based cell of the organization, and said seven of them have been arrested. The eighth, allegedly a leader of the cell, was reported to have been murdered in the Dominican Republic on April 27.

The ringleaders are believed to be outside the United States but prosecutors declined to give details, citing the ongoing investigation. What's clear is the sheer scope and speed of the crimes: in one of the attacks, in just over 10 hours, $40 million was raided from ATMs in 24 countries involving 36,000 transactions.

"In the place of guns and masks, this cyber crime organization used laptops and the Internet," U.S. Attorney for the Eastern District of New York Loretta Lynch said at a news conference. "Moving as swiftly as data over the Internet, the organization worked its way from the computer systems of international corporations to the streets of New York City."

The case demonstrates the major threat that cyber crime poses to banks around the world. It also shows how increasingly international and sophisticated criminal gangs have become, particularly those using the Internet.

Prosecutors highlighted the "surgical precision" of these hackers, the global nature of their organization, and the speed and coordination with which they executed operations in 27 countries.

According to the complaint, the gang broke into the computers of two credit card processors, one in India in December 2012 and the other in the United States this February. The companies were not identified.

The hackers increased the available balance and withdrawal limits on prepaid MasterCard debit cards issued by Bank of Muscat of Oman, and National Bank of Ras Al Khaimah PSC (RAKBANK) of the United Arab Emirates, according to the complaint. They then distributed counterfeit debit cards to "cashers" around the world, enabling them to siphon millions of dollars from ATMs in a matter of hours.

In New York, for example, members of the cell fanned out into the city on the afternoon of February 19, armed with cards bearing a single Bank of Muscat account number. Ten hours later, they had completed 2,904 withdrawals for $2.4 million in all, the final transaction coming around 1:26 a.m., prosecutors said.

Casher crews in other countries were busy doing the same, pulling some $40 million from Bank of Muscat to add to the $5 million they stole from RAKBANK in December, according to the indictment. In total, cashers made some 40,500 withdrawals in 27 countries during the two coordinated incidents.

Prosecutors said the method of attack was known as "Unlimited Operations" in the cyber underworld.

Representatives for the two banks could not be reached for comment outside of regular business hours.

In a statement, Mastercard said it had cooperated with law enforcement in the investigation and stressed that its systems were not involved or compromised in the attacks.

In late February, Bank Muscat disclosed that it would take an impairment charge of up to 15 million rials ($39 million) because it had been defrauded overseas by 12 prepaid debit cards used for travel. That charge was equal to more than half of the 25 million rials profit it posted in its first quarter ended March 31.

Cyber experts said they believe the operation likely required the work of several hundred people, at least several of whom were highly skilled hackers capable of devising ways to penetrate well-protected financial systems.

"Hackers only need to find one vulnerability to cause millions of dollars of damage," said Mark Rasch, a former federal cyber crimes prosecutor, based in Bethesda, Maryland.

The group may have targeted Middle Eastern banks because they tend to allow customers to put much larger sums on cards and do not monitor them as closely as banks in other regions, said Shane Shook, global vice president of consulting for the security firm Cylance Inc.

"It's a target-rich environment in terms of soft electronic security," said Shook, an Arabic speaker who has spent more than a decade investigating cyber crimes.

The case is similar to one in 2009 that targeted the prepaid debit-card unit of Royal Bank of Scotland, which lost more than $9 million in less than 12 hours, said Jason Weinstein, a former federal prosecutor who supervised the Justice Department's handling of that case.

That case was considered a watershed moment in cyber crime prosecutions at the time. "This dwarfs that case," he said.

It is not clear if banks can seek to recover losses from card processors, legal experts said. Contracts usually have specific language governing the security protocols that must be in place, said Frederick Rivera, an attorney with Perkins Coie who specializes in financial services litigation.

If the processors failed to follow those requirements, they could be liable for the losses. If they had adequate security, however, the banks "could be left holding the bag," Rivera said.

The banks might also be able to seek reimbursement under their insurance policies, many of which now have cyber crime provisions, or from the processors' insurance carriers.

Weinstein also said that the processors could face regulatory scrutiny over whether they provided proper security.

The eight defendants - all U.S. citizens and residents of Yonkers, New York - were charged with withdrawing cash from the ATMs and transporting money, not hacking into the credit card processing firms or managing the operation.

The seven arrested are: Jael Mejia Collado, Joan Luis Minier Lara, Evan Jose Peña, Jose Familia Reyes, Elvis Rafael Rodriguez, Emir Yasser Yeje and Chung Yu-Holguin (known as "Chino El Abusador"). All except for Rodriguez were arraigned and pleaded not guilty. Rodriguez's attorney was unavailable. Only Pena has been released on bail.

The defendant who reportedly had been killed was Alberto Yusi Lajud-Peña, also known as "Prime" and "Albertico." Lynch said it was unclear whether the murder was related to this case.

Prosecutors said cashers often laundered their proceeds by purchasing luxury goods, and sending a portion of the money back to the organization's leaders.

Lynch said the New York gang kept roughly 20 percent of their takes, and sent the rest to the organizers. Authorities said they seized hundreds of thousands of dollars in cash and bank accounts, as well as two Rolex watches and a Mercedes SUV, from the defendants.

Investigators said that they found an email exchange with an account associated with a criminal money laundering operation in St. Petersburg, Russia, describing wire transfers.

An investigation is ongoing to see if other cells are operating in the country, Lynch said, adding that U.S. law enforcement had worked with counterparts in Japan, Canada, Germany, Romania, the United Arab Emirates, Dominican Republic, Mexico, Italy, Spain, Belgium, France, United Kingdom, Latvia, Estonia, Thailand, and Malaysia to uncover the ring.

No individual bank accounts were compromised by the scheme, Lynch said.

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Prosecutor to seek murder charges against accused Ohio kidnapper

Cleveland, : An Ohio prosecutor vowed to seek murder charges that could carry the death penalty against a former Cleveland school bus driver accused of kidnapping and raping three young women who endured a decade as captives in his house.

The murder charges against Ariel Castro would stem from forced miscarriages that police say were suffered by one of his victims. Castro was arrested shortly after the women were rescued.

Their imprisonment ended when neighbors, alerted by cries for help, broke through a locked door of Castro's house and freed Amanda Berry, who disappeared the day before her 17th birthday in 2003 on her way home from work at a fast-food restaurant.

Liberated along with Berry, now 27, were her 6-year-old daughter, conceived and born during her confinement, and two fellow captives - Gina DeJesus, 23, who vanished at age 14 after school, and Michelle Knight, 32, who was 20 when she went missing in 2002.

All three told police they were abducted by Castro when they accepted offers of a ride from him in the same West Side Cleveland neighborhood where they were found years later.

Castro, 52, made his first court appearance to face the three counts of rape and four counts of kidnapping he was initially charged with by the city attorney's office, and was ordered to remain in custody on an $8 million bond.

Cuyahoga County Prosecutor Timothy McGinty, who has jurisdiction over all felony cases for Cleveland, said he intends to expand the charges once the case is formally transferred to his office.

"I fully intend to seek charges for each and every act of sexual violence, rape, each day of kidnapping, every felonious assault, and each act of aggravated murder for terminating pregnancies that the offender perpetrated," he said.

Under Ohio law, the crime of aggravated murder includes the unlawful termination of a pregnancy and is a capital offense.

The prosecutor's office will launch the official process to determine if the death penalty is appropriate, McGinty said, adding: "Capital punishment must be reserved for those crimes that are truly the worst examples of human conduct."

Knight suffered at least five miscarriages that she told police were intentionally caused by Castro starving her and beating her in the abdomen, according to an initial police report.

Authorities say all three women were at times bound in chains or rope and were subjected to intimidation, sexual assault, starvation and other abuses during their respective nine, 10 or 11 years of captivity.

The victims told investigators they recalled leaving the confines of the house just twice during their ordeal, ushered on both occasions into a separate garage on the property while disguised in wigs and hats.

During his initial hearing in municipal court, which lasted less than five minutes, Castro neither spoke nor entered a plea, and kept his face turned away from a courtroom gallery crowded with media and spectators.

Castro's home "was a prison to these three women and the child," Cuyahoga County Assistant Prosecuting Attorney Brian Murphy told the judge. "Today the situation is turned on him. ... Mr. Castro stands before you a captive, in captivity, a prisoner."

The prosecutor's office declined to comment on a CNN report, attributed to an unnamed law enforcement source, that Castro had confessed under questioning to some of the actions of which he has been accused.

Castro's court-appointed lawyer, Kathleen DeMetz, said her client would be placed on a suicide watch in jail and was expected to be held in isolation.

In order to win release on bail, he would need $800,000 cash - 10 percent of the bond amount.

"The man doesn't have any money," Metz said. "He clearly doesn't have that," noting that Castro had been unemployed since being fired from his job driving school buses last November.

Berry told police that her escape had been her first chance to break free in the 10 years that she was held, seizing the opportunity during Castro's momentary absence.

Her baby was born in a plastic inflatable children's swimming pool on Christmas Day, 2006, authorities said. A paternity test will be conducted to determine the girl's father.

McGinty, the county prosecutor, said assembling a multitude of charges against Castro could take time, considering the ordeals the victims experienced.

"They need a chance to heal before we can seek further in-depth evidence from them," he said, describing them as having "found the internal strength and courage to outlast their tormentor and survive a decade of torture and depravity."

Berry and DeJesus went home with family members, while Knight remained hospitalized in good condition.

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Bail set at $8 million for kidnap suspect; prosecutor may seek death penalty

Cleveland, (Newswire): A judge set bail at $8 million at a brief hearing for Ariel Castro, the Cleveland man accused of kidnapping and keeping three young women as captives for a decade. The lawyer prosecuting the case said he may seek the death penalty against Castro.

Cleveland Municipal Judge Lauren C. Moore set bail at $2 million per charge, an amount that indicated the judge wants to keep Castro in jail. He was ordered not to have any contact with the three women or their families.

Castro appeared in court along with his brothers, Pedro, 54, and Onil, 50. All three were handcuffed, but Onil and Pedro Castro were not charged. They appeared before the same judge this morning on outstanding misdemeanors and were released around noon.

The Cleveland Police Department announced it had handed over custody of Ariel Castro had to county authorities.

Castro, 52, is charged with four counts of kidnapping and three counts of rape. Police say the former school bus driver held Amanda Berry, 27, Gina DeJesus, 23, and Michelle Knight, 32, at his west side Cleveland home. The women were reportedly restrained with ropes and chains. Court documents indicate Castro repeatedly raped the women throughout their captivity.

Timothy McGinty, a Cuyahoga County prosecutor leading the case, said he and his team are evaluating whether to pursue charges eligible for the death penalty, which he said should be reserved for the "worst examples" of human conduct.

"I fully intend to seek to charges on each and every act of sexual violence, rape, each day of kidnapping, every felonious assault, all these attempted murders, and each act of aggravated murder he committed by terminating pregnancies that the offender perpetuaged against the hostages during this decade-long ordeal," McGinty told reporters at a news conference.

Knight was taken on Aug. 22, 2002, Berry on April 21, 2003, and DeJesus on April 2, 2004.

Berry, who went missing a day before her 17th birthday after leaving her job at a nearby fast-food restaurant, broke free from Castro's home with her 6-year-old daughter, Jocelyn. After she called police, DeJesus and Knight were able to escape, too.

Court records indicate that in each case, Castro lured the victim into his car and took her to his Seymour Avenue home. Deputy Police Chief Ed Tomba told reporters that the women, as well as Ariel Castro, have given lengthy statements to police.

The women had several miscarriages during their captivity, police said.

Berry gave birth to Jocelyn on Dec. 25, 2006. Police said the girl was born in an inflatable swimming pool. The fourth kidnapping charge against Castro came from holding the girl, whom court papers identify as Jane Doe, in captivity as well.

Despite the gruesome details, Terry Gilbert, a Cleveland-based criminal defense lawyer, said prosecutors are facing a challenge proving aggravated murder against Castro.

Under Ohio law, a person can be charged with murder for causing the termination of a pregnancy. The prosecution, however, will need physical, medical, and forensic evidence in this case, Gilbert said.

“You’re going to have to have a body,” he said. “Somebody just saying that (the women's pregnancies were terminated) may not be enough.”

Gilbert also said the case may not fit as a death penalty case because defense attorneys would argue whether aggravating specifications—kidnapping, assault, and crimes beyond murder—can be applied to a fetus.

“There’s a lot of road blocks to get to (the death penalty),” Gilbert said. “It would be a highly unusual and difficult kind of prosecution to make.”

As they entered court, Pedro and Onil were looking up. Ariel Castro consistently looked down and never faced the court.

Public defender Kathleen DeMetz said she had met with Ariel Castro for about 30 minutes before the arraignment began to review the charges against him and brief him on how the proceedings would unfold. She would not comment on his demeanor or what he said to her.

Brian Murphy, an assistant Cuyahoga County prosecutor, told the judge Castro "snatched" the three women off the streets of Cleveland. He asked that the court set bond at $5 million and that Castro not be allowed to have any contact with women or their families, whether he gets out on bond or not.

DeMetz told the judge that Castro has lived in the area for the past 32 years, is unemployed and, to her knowledge, had no prior convictions. After the hearing, DeMetz said it would be highly unlikely that he would make bond.

"He would have to come with $800,000 cash to get out," DeMetz said. "He clearly does not have that."

While Knight remains in a local hospital, both Berry and DeJesus were escorted home by police motorcades to raucous crowds

Berry and her daughter went to Berry's sister’s home, while DeJesus returned to her parents' tan bungalow. Both families live just a few miles from the ramshackle row house where they were apparently held as prisoners.

Berry’s sister, Beth Serrano, briefly addressed the crowd outside her home and said that Berry needed time to recover before talking publicly about her ordeal.

“At this time our family would request privacy so my sister, niece and I have time to recover,” Serrano said. “We appreciate all you have done for us for the past 10 years. Please respect our privacy until we are ready to make our statement."

Later in the day, DeJesus, wearing a bright yellow hoodie, was quickly taken inside her home without speaking or showing her face. She was seen giving a thumbs-up to the crowd of reporters and onlookers assembled outside.

Her parents, Felix DeJesus and Nancy Ruiz, and aunt Sandra Ruiz thanked the police and FBI for their assistance in the investigation. They asked for patience and promised to take questions from reporters soon.

“The three of them are doing great. Those were miracles," Nancy Ruiz said of her daughter, Berry and Knight.

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Jimmy Carter named most trusted U.S. politician in new poll

Washington, (Newswire): Americans really, really trust Hollywood. They are, however, far more skeptical of Washington, D.C.

A new survey on the most trusted people in America finds actors taking the top three spots: Tom Hanks, Sandra Bullock and Denzel Washington. The first politician to appear on the list is former President Jimmy Carter, who comes in at number 24.

Carter, 88, often referred to as the most successful ex-president in American history, has earned bipartisan praise since leaving office for his work on behalf of various humanitarian causes.

During his successful 1976 presidential campaign, Carter won over a majority of American voters with his “Trust Me” campaign slogan.

The surveyed asked 1,000 participants who they trusted the most and was conducted by The Wagner Group for Readers Digest.

President Obama made the list as well but came in at number 65.

According to the list, Obama was edged out by none other than Adam Sandler, named the 64th most trusted person in America.

No other former president made the list, though Hillary Clinton, a potential 2016 candidate, came in at number 51.

The president was also far outclassed by his own wife. Michelle Obama was the top-ranked Washingtonian on the list, coming in at number 19. Unless you count Clint Eastwood, came in at number 13 on the list.

Obama did edge out Supreme Court Justice Antonin Scalia, who was listed number 66 in the poll.

The most popular judicial figure on the list? Well, that would be Judith Sheindlin, “Judge Judy,” who beat out all nine Supreme Court justices, coming in at number 29 on the list.

Of course, all of these numbers are slightly skewed. Reader’s Digest notes that the top three choices, by far, were “your own doctor” (77%), “your own spiritual adviser” (71%), and “your own child’s current teacher” (66%). Those responses were removed to focus on public figures.

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Washington State system hacked, data of thousands at risk

Seattle, (Newswire): The website for the Washington State court system has been hacked and up to 160,000 Social Security numbers and a million driver's license numbers may have been accessed, officials said.

The disclosure, which follows a number of major hacking incidents in recent years that have targeted a range of companies from Twitter to Apple Inc, raises concerns that the information accessed could be used to commit financial fraud.

The breach was discovered in February, and officials at first believed no confidential information had been leaked even though a large amount of data was downloaded from the website, the Washington State Administrative Office of the Courts said.

But officials later determined that 94 Social Security numbers were definitely obtained by the person or group that committed the security breach, while 160,000 Social Security numbers and a million driver's license numbers may have been accessed.

"The access occurred through a ‘back door' part of a commercial software product we were using, and it is patched now," Mike Keeling, information technology operations and maintenance manager for the court system, told reporters on a conference call.

"We found specific (hacker) footprints in the area where those 94 Social Security numbers were located, so that's why we're reasonably sure that the data was accessed," he said.

Callie T. Dietz, the state's court administrator, said this was the first time the agency's system had been hacked. Officials were notifying by mail the 94 people whose Social Security numbers were accessed from the site.

"We regret that this breach has occurred and we have taken immediate action to enhance the security of these sites," Dietz said separately in a statement.

The people whose names and Social Security numbers might be at risk are those who were booked into a city or county jail in the state from September 2011 to December 2012, officials said.

The breach could also have exposed the driver's license numbers of people charged in the state's superior court criminal system between 2011 and 2012, the statement said.

Anyone who received a driving under the influence citation from 1989 to 2011 or had a traffic case filed or resolved in a district or municipal court between 2011 and 2012 might also be at risk, officials said.

No financial data such as credit card numbers was maintained on the court website, so officials said there was no risk of that information being accessed directly through the breach.

The breach was the latest in a series of hacks. In one prominent case, Cody Kretsinger of LulzSec, an offshoot of hacking group Anonymous, last year pleaded guilty in federal court in Los Angeles to taking part in a computer breach of Sony Pictures Entertainment that prosecutors say caused over $600,000 in damages. Last month, he was sentenced in California to a year in prison.

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Enzi pushes back release of mineral payments bill

Cheyenne, (Newswire): Wyoming's senior U.S. senator is delaying the release of legislation that aims to block the federal government from cutting mineral royalty payments to 35 states.

Sen. Mike Enzi, R-Wyo., had said he planned to release a bill this week after the Department of Interior announced it would make $110 million in cuts this year.

Daniel Head is a spokesman for Enzi in Washington. He said that the senator now plans to release the bill next week because he's working to gather more supporters in the House.

As the nation's leading coal-producing state, Wyoming stands to lose more than $50 million in royalties for minerals mined from federal land.

Interior Secretary Sally Jewell said this week that her agency had no choice but to trim the payments because of the automatic federal budget cuts.

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American Airlines settles safety claims for $24.9M

Dallas, May 23 : American Airlines has agreed to pay $24.9 million to settle $162 million in potential fines that were proposed by U.S. safety regulators.

American called the payment "a reasonable resolution" to the Federal Aviation Administration's claims that it had violated safety regulations involving electrical wiring on planes and other issues.

The airline's parent company, AMR Corp., disclosed the settlement in a filing with the federal bankruptcy court in New York.

Airlines frequently negotiate with the FAA to reduce potential penalties. A spokeswoman for American said the airline was pleased with the settlement over a claim that FAA had lodged during AMR's bankruptcy reorganization.

"This settlement recognizes the many changes, including enhancements to our maintenance and engineering processes, increased training, inspections, and audits that have taken place at American over the past several years that address past FAA concerns," the spokeswoman, Andrea Huguely, said in a statement.

American, its American Eagle regional-flying affiliate and two other AMR subsidiaries denied wrongdoing. But, they said, the outcome of litigation with the FAA can be uncertain and the settlement was good business judgment.

The settlement is subject to the bankruptcy court's approval. AMR expects to emerge from bankruptcy protection and merge with US Airways Group Inc. by the end of September.

Among the complaints covered by the settlement was the 2008 grounding of American's fleet of McDonnell Douglas MD-80 aircraft — and the cancellation of thousands of flights — over electrical wiring. The FAA said that American's crews had failed to follow proper procedures in restraining electrical wires on many planes, raising the risk of fires and fuel-tank explosions.

In 2010, the FAA proposed a record penalty of $24.2 million in that case. The airline insisted that passenger safety was never compromised and that the FAA's charges were overblown.

The FAA was investigating American for possible violations of other safety rules when AMR filed for bankruptcy protection in November 2011. Last summer, the agency filed a claim in bankruptcy court for up to $162.4 million. The FAA had not even notified AMR about some of the charges, but the agency rushed to beat a deadline for filing claims and becoming a creditor.

The FAA's biggest claim — $39.3 million — involved allegations that American used Boeing 757 jets on flights before proper inspections and repairs were finished. A claim of $28.8 million involved charges that American didn't follow Boeing's recommended procedures for overhauling the main landing gear on about 30 jets, and a $27.6 million claim involved work on the engines of different Boeing planes.

All were investigated as civil cases. The FAA said in the settlement agreement that it didn't find criminal wrongdoing or evidence strong enough to suspend American's operating certificate.

FAA officials declined to comment.

The potential penalties covered alleged safety violations from 2007 through 2011. About $156.5 million involved American Airlines, $5.3 million dealt with Eagle, and $647,000 involved two other AMR subsidiaries. Of the settlement, $24 million covers cases at American. 

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S&P 500 slips, snaps five-day streak of record closes

New York,  : The S&P 500 broke a five-day streak of record closing highs, ending a fairly volatile session lower as the market's recent momentum faded and Apple's shares declined.

The Dow also broke its two-day string of all-time closing highs, but still ended above 15,000.

The length of the recent rally has surprised many investors. Analysts said it's difficult for the upward momentum to continue without further catalysts, such as first-quarter earnings reports, which are nearing an end.

Volume was the highest of the week so far, giving more weight to the day's decline. Much of this year's rally has been on weak volume.

"This market is so stretched to the upside that if we get some little wiggle somewhere, I can easily see us getting back down to 1,580" on the S&P 500, said Stephen Massocca, managing director of Wedbush Equity Management LLC in San Francisco.

Apple (AAPL.O), down 0.9 percent at $456.77, led the declines of both the S&P 500 and the Nasdaq, while International Business Machines (IBM.N), down 0.8 percent at $203.24, was the biggest drag on the Dow.

The day's economic data was mostly positive, but failed to give much of a boost to stocks. The number of Americans filing new claims for unemployment benefits fell last week to the lowest level in almost 5-1/2 years - contrary to economists' forecast of a gain - U.S. Labor Department data showed.

The Dow Jones industrial average (.DJI) fell 22.50 points, or 0.15 percent, to end at 15,082.62. The Standard & Poor's 500 Index (.SPX) declined 6.02 points, or 0.37 percent, to finish at 1,626.67. The Nasdaq Composite Index (.IXIC) slipped 4.10 points, or 0.12 percent, to close at 3,409.17.

After the bell, shares of Priceline (PCLN.O) fell 3.3 percent to $713 after the online travel agency forecast second-quarter profit would fall below analysts' estimates.

Despite the declines for the day, both the Dow and the S&P 500 reached all-time intraday highs - with the Dow touching 15,144.83 and the S&P 500 reaching 1,635.01.

The market, which had been down slightly from the opening bell through midday, reversed course and began to edge higher in early afternoon. Stocks gave up those gains later in the session.

Limiting the S&P 500's loss, News Corp (NWSA.O) shares gained 4.5 percent to $33.29. It reported earnings that beat expectations while revenue rose 14 percent. Rupert Murdoch's media company also said it was on track to split off its slow-growing publishing business by the end of June.

Among other top advancers, Tesla Motors Inc (TSLA.O) surged 24.4 percent to $69.40 a day after posting adjusted earnings that were three times what analysts were expecting as the company sold more cars than it had initially forecast.

Shares of Barnes & Noble Inc (BKS.N) shot up 24.3 percent to $22.08, after hitting a fresh 52-week high of $22.25. The stock's sharp advance followed a report by web publication TechCrunch that Microsoft Corp (MSFT.O) was considering an offer to acquire all of Nook Media's digital assets for $1 billion. Microsoft shares slipped 1 percent to $32.66.

Both Barnes & Noble and Tesla Motors have been among favorite stocks to short, and their gains were likely extended by traders who were forced to cover bets the stocks would fall in order to prevent further losses.

Volume was roughly 6.4 billion shares traded on the New York Stock Exchange, the Nasdaq and the NYSE MKT, matching the average daily closing volume this year.

Decliners outnumbered advancers on the NYSE by a ratio of nearly 2 to 1 and on the Nasdaq, about three stocks fell for every two that rose.

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Amplats set to announce details of revised restructuring plan

Johannesburg, May 23 : Anglo American Platinum (AMSJ.J) said it would announce the details of its revised plan to turn around its struggling South African operations at midday South African time.

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Dollar hits 100 yen, stocks slip after rally

New York, May 23 : The U.S. dollar broke through 100 yen, its highest level against the currency in over four years, while stocks in major markets slipped from recent record levels.

Investors sold the low-yielding yen as support from central banks around the world continued to push cash into higher-yielding assets. U.S. stocks fell slightly after recent gains from a rally that had taken the S&P 500 index to record highs for five straight sessions.

The dollar got support from U.S. data showing first-time applications for unemployment insurance fell last week to the lowest level in more than five years.

"A stampede out of safety and brightening U.S. job prospects helped catapult the dollar over the key triple-digit threshold against the yen," Joe Manimbo, senior market analyst at Western Union Business Solutions in Washington, said in a note.

The yen is on track for eight straight months of declines against the greenback, shedding more than 30 percent since its September high near 77. A major stimulus program by the Bank of Japan last month to revive the economy has helped prolong the yen's weakening trend.

U.S. stocks slipped but the recent uptrend remains intact, giving room for declines after the strong climb.

"This market is so stretched to the upside that if we get some little wiggle somewhere, I can easily see us getting back down to 1,580" on the S&P 500, said Stephen Massocca, managing director of Wedbush Equity Management LLC in San Francisco.

Pullbacks in U.S. equities have been short-lived and shallow even as traders have said the market could benefit from a correction. The expectation of continued accommodative monetary policy from central banks globally has sustained support for stocks.

At the close the Dow Jones (DJI: ^DJI - news) industrial average fell 22.5 points or 0.15 percent, to 15,082.62, the S&P 500 lost 6.02 points or 0.37 percent, to 1,626.67 and the Nasdaq Composite dropped 4.1 points or 0.12 percent, to 3,409.17.

The Euro STOXX 50 index dropped 0.4 percent, retreating from a near two-year high but finding support at an upward trendline from lows hit on April 18. The pan-European FTSEurofirst closed flat to stay near five-year highs.

The MSCI world index, which tracks stocks in 45 countries, was down 0.7 percent after earlier hitting its highest level since June 2008.

The U.S. dollar rose against major currencies almost 1 percent and above its 14- and 50-day moving averages.

The yen closed the session down 1.6 percent at 100.59 per dollar.

The euro was down 0.8 percent at $1.3045 after earlier hitting a high of $1.3177.

The euro was pressured by slightly softer-than-expected demand at a Spanish debt auction, while Spanish government bond yields rose.

Brent crude edged up in volatile trade and U.S. crude settled slightly down, as investors weighed Middle East tensions against weak demand and high inventories.

U.S. oil fell 23 cents to settle at $96.39 a barrel and was down further in extended trading. Brent crude edged up 13 cents to settle at $104.47 per barrel and later dropped 9 cents to $104.25.

Brent has dipped from a one-month high of $105.94 touched after Israeli air strikes on Syria over the weekend stoked supply fears.

"There's a tug of war here; the demand is not going to be there, but the economy is slowly improving," said Mark Waggoner, president at Excel Futures in Bend, Oregon.

Saudi Arabia increased crude oil output by 160,000 barrels per day to 9.3 million bpd in April, industry sources said this week, adding to an already well-supplied global market.

Spanish bond yields rose on speculation Madrid may be planning another bond sale after borrowing costs fell at auction of just over 4.5 billion euros of new debt.

The country's 10-year bond yields were 8 basis points higher at 4.195 percent, having moved away from the 2-1/2 year lows of 3.954 percent touched.

Prices for U.S. Treasuries were flat as investors balanced stronger-than-expected jobs data with expectations that riskier assets such as equities could see a correction soon.

The U.S. 10-year Treasury note yield inched up to 1.811 percent, the highest in nearly a month. The U.S. 30-year bond traded down 5/32 to yield 2.994 percent from 2.987 percent.

Gold prices fell after the U.S. jobs data, with dollar strength weakening the price further. Spot gold was down 1 percent to $1,456.69. The metal gained 1.4 percent in the previous session, its biggest one-day rise in two weeks.

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China issues new rules targeting wealth management fund pools

Shanghai, (Newswire): China's bond market regulator closed off a loophole that allowed banks that sell high-yielding wealth management products (WMPs) to evade regulatory requirements by moving money between the WMP accounts they manage and their own proprietary accounts, bond traders at four Chinese banks said.

The four traders, who spoke on condition of anonymity because they are not authorized to speak to media, said the China Government Securities Depository Trust & Clearing Co Ltd (CDC) and the Shanghai Clearing House had jointly notified commercial banks they could no longer trade bonds between their own proprietary accounts and the WMPs they manage for clients.

The rules will go into effect, the sources said.

"Yesterday we could do it, today everybody has to undo it; it's new regulation after new regulation," said one of the traders.

The CDC did not answer calls requesting comment.

The traders said the new rule would prevent a common practice in which banks shift bonds back and forth between their own balance sheets and the WMP accounts they manage for clients, allowing them to deliver promised payouts to WMP investors, even if the underlying bonds have not yet matured or have declined in value.

Such transactions have also enabled banks to temporarily shift WMP funds back onto bank balance sheets at quarter-end, as a way to window dress their financial statements by boosting the customer deposits they report.

In other cases, a bank may use its own account to purchase a bond in the primary market before it has completed fundraising for a WMP, then sell the bonds on to the WMP account later. That allows the banks to deliver higher yields to their WMP investors, since yields are typically higher in the primary market.

The China Banking Regulatory Commission (CBRC) announced a crackdown on fund pooling in January, and has been implementing new rules ever since.

Industry observers are concerned that the practice is akin to a Ponzi scheme because of the way such pools allow inflows from the sale of new products to deliver the promised returns on previously issued products.

The complex and interlocking nature of such pools, supporting a wide variety of different WMPs with different maturity periods, also exposes banks to significant liquidity risk, analysts have warned.

The rise of WMPs has been fuelled by Chinese depositors' hunger for yields above the central bank's benchmark deposit rate, currently set at 3.0 percent for one year, and economists say Beijing has tolerated the explosive growth in the sector because WMPS can deliver higher yields to ordinary investors, serving as a backdoor way to liberalize interest rates and increase the propensity to consume.

Banks have been quick to issue WMPs to attract customers, and also sell third-party WMPs through their retail channels.

However, the collapse of several WMPs amidst fraud allegations, and the generally opaque nature of the products has attracted concern. State media has taken to warning investors that such products are not tacitly guaranteed by the government, but China has yet to experience a corporate bond default.

Standard & Poors estimated that WMPs offered by Chinese banks grew 56 percent in 2012 to 7.12 trillion yuan ($1.16 trillion), equivalent to 7.6 percent of the system's total deposits at the end of the year.

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Keep on, or enough already? Fed officials spar over QE3

San Francisco, May 22 : Little over a week after U.S. Federal Reserve policymakers overwhelmingly endorsed a plan to keep buying bonds to spur economic growth and hiring, they are airing their differences over their super-easy policy.

"I think we should try as hard as we can" to turn things around, Chicago Federal Reserve Bank President Charles Evans said in an interview on Bloomberg TV, in a forceful defense of the bond-buying program, known as QE3 because it is the Fed's third round of quantitative easing since the Great Recession.

Crediting QE3 for a "definitely" improved labor market, he said the Fed should not back away from the program. "I'd like to have confidence we can sustain that improvement in the labor market through this summer," he said.

Though the U.S. central bank renewed its commitment last week to buy $85 billion in bonds per month and to keep rates low for some time to come, weaker inflation on the one hand and a steady drop in unemployment on the other have investors anxiously guessing when monetary policy will shift.

Philadelphia Fed President Charles Plosser, a policy hawk and unlike Evans not a voting member of the Fed's policy committee this year, took the opposite tack and called the effects of the bond-buying program "dubious."

"I've never felt that our asset purchases have been that effective in addressing what's the biggest problem we face in this country, which is the employment market and the labor market," he told Bloomberg television separately.

"I'd like to stop but I would particularly like to see us begin to slow the pace down, gradually ease our way out of this if we possibly can."
 
Later, Plosser told reporters in New York that he is "not too concerned" about weaker recent U.S. inflation readings, arguing the Fed should move to stave off disinflation only if expectations begin to fall.

"I do believe we have to defend our inflation target (of 2 percent) both on the upside and the downside and it's important to do so," he added. "But as long as inflation expectations remain well anchored I'm reasonably comfortable."

Strong differences of opinion among policymakers at the U.S. central bank are not unusual, and Plosser and Evans in particular have long sparred from opposite ends of the policy spectrum.

Investors will be watching closely for any hints from Fed Chairman Ben Bernanke about his policy outlook when he gives a speech at the Chicago Fed.

Unemployment fell to 7.5 percent last month, continuing a steady but slow three-year decline, and last week the number of Americans filing new claims for unemployment benefits dropped to its lowest level in nearly 5-1/2 years.

But other economic signals have been less encouraging, including inflation that has dropped now to about half the Fed's 2-percent target.

Low inflation has in fact prompted one policymaker, St. Louis Fed President James Bullard, to suggest the Fed may need to add to its stimulus to defend the economy against a possible sustained drop in prices.

But on Evans, whose views have been in step with those of Bernanke, said he believes the drop in inflation is temporary, and does not call for any immediate Fed policy response.

Evans, who is hosting the Chicago Fed's annual bank structure conference this week, and Plosser and Richmond Fed President Jeffrey Lacker also waded into the debate over capital standards for banks. They were far more unanimous on that topic.

The debate about "too-big-to-fail" banks, which are perceived as implicitly relying on taxpayers to bail them out no matter how risky their business conduct, has heated up in Washington in the last few weeks.

Some regulators and other critics of the Basel III international agreement to protect against another global financial crisis have said it is too easy on banks, and that it relies too much on letting banks use complex calculations to determine how much equity they should hold.

Speaking elsewhere in New York, Lacker said that requiring banks to hold more debt that converts into equity when the firms get into trouble, an idea backed by Fed Governor Daniel Tarullo, is one way to ramp up capital though perhaps not the best.

He also said that broker dealers "deserve special attention" in this debate.

Some of his colleagues, including Boston Fed President Eric Rosengren, have suggested requiring higher capital at such firms.

Evans argued that financial institutions should have better quality and more capital to buffer themselves against sudden losses, while Plosser said the United States is falling short in its effort to end the too-big-to-fail problem, almost three years after it adopted the Dodd-Frank financial reform law.

Plosser said regulators like the Fed should require higher capital from banks and adopt a fresh approach to winding down firms that face bankruptcy. "Can we end too big to fail? I think we can, but I believe the current efforts may come up short," he said.

Addressing another of the Fed's concerns as it supports the U.S. economy and supervises its financial sector, Fed Governor Elizabeth Duke said a recovery has taken root in the U.S. housing market. In Washington, she argued that resolving uncertainty over mortgage regulations would make the recovery stronger.

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Icahn, Southeastern propose alternative to Dell buyout deal: WSJ

New York, (Newswire): Activist investor Carl Icahn and Southeastern Asset Management Inc, two of Dell Inc's largest shareholders, have proposed an alternative to a $24.4 billion buyout deal led by founder Michael Dell, the Wall Street Journal reported.

Icahn and Southeastern, both vocal opponents of the deal, proposed giving Dell shareholders the option to keep holding stock in the company and take an additional $12 a share in cash or stock in a letter to Dell's board, the paper said.

The letter said Icahn and Southeastern together hold 13 percent of Dell's stock. The duo have argued that the buyout effort from Michael Dell and private-equity firm Silver Lake Partners significantly undervalues the company, according to the paper.

In April, Blackstone pulled out just a month after it launched a challenge to the billionaire's attempt to take Dell private. Icahn and Blackstone each offered alternatives that would keep part of the company public.

Representatives for the PC maker could not immediately be reached for comment outside of regular U.S. business hours.

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Sopore man electrocuted

Sopore, (Newswire): A 45-year-old man was electrocuted in his home at Dobgah area here in held Kashmir.

The deceased Ghulam Rasool Khan is survived by three children and a wife.

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‘Kashmir being supplied with poor quality mutton’

Srinagar,(Newswire): The Peoples Voice Civil Society expressed serious concern over what it said “supply and sale of third grade quality mutton in Kashmir.”

A PVCS delegation presented a memorandum to the Divisional Commissioner saying that held Kashmir was being supplied with poor quality mutton. 

The delegation informed the Div Com that the butchers were overcharging from the consumers and sought action from the government officials concerned against the culprits.

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Students, parents demand release of re evaluation results

Srinagar, (Newswire): Students who had applied for re evaluation of their papers in class 12th have demanded early release of results of the re evaluation of the papers they had applied for.

They criticized the Board of School Education for delay caused in the declaration of these results saying that this is marring their career prospects as many of them have applied for courses within and outside the state.

A group of parents told Greater Kashmir that the result of 12thstandard examination was declared on January 23, 2013 and within 15 days the JKBOSE authorities accepted the re-evaluation Application Forms.

 They said it is now about five months the results of these thousands of students are not being declared and now the last date of submission of other Forms at various places is also nearing ending.

 The aggrieved parents said they are worried about the career of their wards, as these are at stake due to the delay in declaration of results of re-evaluation and also in the conduct of the examination in the re-appear papers.

 It may be mentioned here that the last date of submission of forms for many prestigious professional exams is fast nearing expiry within few days now.

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Enzyme may drive breast cancer growth

Islamabad, (Newswire): A recently discovered enzyme drives the production of a potent form of estrogen in human breast cancer tissue, researchers from the University of Illinois at Chicago College of Medicine have found.

The extra-strength estrogen, called estradiol, then drives the production of even more enzyme, in what may be a lethal feed-forward mechanism. Estradiol has been implicated in exacerbating tumor growth in breast cancer.

The research is published in the journal Molecular Endocrinology.

Scientists had observed the increased production of an unknown protein in ovarian tissue in response to estrogen. UIC researchers under the direction of Geula Gibori, UIC professor of physiology and biophysics, then purified the protein and cloned its gene. Several laboratories established that it is an enzyme that converts a weak estrogen, estrone, to the much more potent estradiol.

The UIC researchers then examined the production of the enzyme in a line of breast cancer cells known to respond to estrogen levels.

"Estradiol up-regulates the very enzyme that produces estradiol, creating a positive cycle where this potent form of estrogen is being produced over and over again, sustaining its own production," said Aurora Shehu, UIC postdoctoral research associate in physiology and biophysics and first author of the study.

In human breast tissue, the researchers found a "dramatic" up-regulation in the cancerous cells but not in the surrounding benign tissue, said Gibori, who is principal investigator on the study. The surrounding tissue, however, is a rich source of the estrone that the enzyme needs to produce more estradiol, she said.

The researchers were able to show how estradiol turns on the gene that produces the enzyme, and that this activation also required at least one other known regulatory factor.

They found that tamoxifen, a drug widely used to inhibit breast cancer growth, prevents estradiol's stimulation of the enzyme and thus may shut down local production of estradiol in breast cancer cells.

"Breast cancer tumors with this enzyme are likely to be a much more aggressive and potentially deadly type of cancer," Gibori said. "Identifying this enzyme and how its expression is turned on gives medical researchers potential targets for disrupting the lethal production of estradiol in breast cancers."

The enzyme is a promising therapeutic target because blocking it may halt production only of the dangerous estradiol, which would reduce the side effects seen with other drugs that inhibit production of many estrogen-related compounds, Gibori said.

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Wii key to helping kids balance

Islamabad, May 23 (Newswire): By cleverly linking five Wii Balance Boards, a team of Rice University undergraduates has combined the appeal of a video game with the utility of a computerized motion-tracking system that can enhance the progress of patients at Shriners Hospital for Children-Houston.

The Rice engineering students created the new device using components of the popular Nintendo game system to create a balance training system.

What the kids may see as a fun video game is really a sophisticated way to help them advance their skills. The Wii Balance Boards lined up between handrails will encourage patients age 6 to 18 to practice their balance skills in an electronic gaming environment. The active handrails, which provide feedback on how heavily patients depend on their arms, are a unique feature.

Many of the children targeted for this project have cerebral palsy, spina bifida or amputations. Using the relatively inexpensive game console components improves the potential of this system to become a cost-effective addition to physical therapy departments in the future.

Steven Irby, an engineer at Shriners' Motion Analysis Laboratory, pitched the idea to Rice's engineering mentors after the success of last year's Trek Tracker project, a computer-controlled camera system for gait analysis that was developed by engineering students at Rice's Oshman Engineering Design Kitchen (OEDK)..

The engineering seniors who chose to tackle this year's new project -- Michelle Pyle, Drew Berger and Matt Jones, aka Team Equiliberators -- hope to have the system up and running at Shriners Hospital before they graduate next month.

"He (Irby) wants to get kids to practice certain tasks in their games, such as standing still, then taking a couple of steps and being able to balance, which is pretty difficult for some of them," Pyle said. "The last task is being able to take a couple of steps and then turn around."

"This isn't a measurement device as much as it is a game," Irby said. "But putting the two systems together is what makes it unique. The Wii system is not well suited to kids with significant balance problems; they can't play it. So we're making something that is more adaptable to them."

The game requires patients to shoot approaching monsters by hitting particular spots with their feet as they step along the Wii array, computer science student Jesus Cortez, one of the game's creators, explained. The game gets harder as the patients improve, he said, and the chance to rack up points gives them an incentive.

A further step, not yet implemented, would be to program feedback from the handrails into the game. Leaning on the rails would subtract points from the users' scores, encouraging them to improve their postures. The game would also present challenges specific to younger and older children to keep them engaged.

The programming team also includes undergraduate Irina Patrikeeva and graduate student Nick Zhu. Studio arts undergraduate Jennifer Humphreys created the artwork.

The system's components include a PC, the Wii boards (aligned in a frame) and two balance beam-like handrails that read how much force patients are putting on their hands. Communications to the PC are handled via the Wii's native Bluetooth protocol.

The students said their prototype cost far less than the $2,000 they'd budgeted. Rice supplied the computer equipment and LabVIEW software they needed to create the diagnostic software that interfaces with Shriners' existing systems, and they purchased the Wii Balance Boards on eBay.

"Small force plates that people commonly use for such measurements cost at least a couple of grand, but Wii boards -- and people have done research on this -- give you a pretty good readout of your center of balance for what they cost," Pyle said.

Jones, who is building the final unit for delivery to Shriners, said he wants patients to see the Wii boards. "We're putting clear acrylic over the boards so there aren't any gaps that could trip up the younger ones," he said. "We wanted to use a device that's familiar to them, but they might not be convinced it's a Wii board unless they can see it."

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Too much of a good thing: important mechanism in hormone-sensitive breast cancer uncovered

Islamabad, (Newswire): Two thirds of breast cancers are ERalpha-positive, i.e., many estrogen receptors of the ERalpha- type are found in their cells. "These molecules can interact with the estrogen hormone and, thus, even lead to cancer," explains Dr. Joerg Hoheisel; molecular biologist at DKFZ. 

"The connection between the levels of the estrogen receptor alpha and the occurrence of breast cancer has been known for some time now. Early-stage breast cancer cells already produce too many of these receptors. This is associated with increased cell division, which is ultimately responsible for tumor development," says Hoheisel.

Jointly with his coworkers, Dr. Yasser Riazalhosseini and Pedro de Souza Rocha Simonini, Joerg Hoheisel has now been able to show that a tiny little nucleic acid, a microRNA known as miR-375, causes the high receptor levels which, in many cases, lead to cancer. MicroRNAs are important intracellular signal mediators, which have a substantial influence on the effectiveness of genes. 

The DKFZ group discovered that miR-375 blocks the production of an enzyme which influences the production of ERalpha-receptors. Thus, high levels of miR-375 lead to production of many estrogen receptors. At the same time, elevated ERalpha-levels lead to production of more miR-375. This feedback loop further boosts the multiplication of cancer cells.

The research group headed by Joerg Hoheisel has now published the results of their experiments in the journal Cancer Research. They also present a first indication of a possible medical application of the newly gained knowledge: "We were able to block the miR-375 microRNA in ERalha-positive breast cancer cells. This effectively slowed down cancer cell growth." Whether and how miR-375 will play a role in breast cancer treatment in the future is a question which Hoheisel cannot answer yet. "But we hope to be able to use our results in the future for developing new strategies against tumors with too many estrogen receptors."

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