Computer analysis predicted rises, ebbs in Afghanistan violence

Tuesday, 23 July 2013

Kabul, July 24 (Newswire): In August 2010, shortly after WikiLeaks released tens of thousands of classified documents that cataloged the harsh realities of the war in Afghanistan, a group of friends — all computer experts — gathered at the New York City headquarters of the Internet company Bitly Inc. to try and make sense of the data.

The programmers used simple code to extract dates and locations from about 77,000 incident reports that detailed everything from simple stop-and-search operations to full-fledged battles. The resulting map revealed the outlines of the country's ongoing violence: hot spots near the Pakistani border but not near the Iranian border, and extensive bloodshed along the country's main highway. They did it all in just one night.

Now one member of that group has teamed up with mathematicians and computer scientists and taken the project one major step further: They have used the WikiLeaks data to predict the future.

Based solely on written reports of violence from 2004 to 2009, the researchers built a model that was able to foresee which provinces would experience more violence in 2010 and which would have less. They could also anticipate how much the level of violence went up or down.

The project, whose results were published online by the Proceedings of the National Academy of Sciences, is part of a growing movement to understand and predict episodes of political and military conflict using automated computational techniques.

The availability of huge amounts of data combined with steady increases in computing power has prompted experts to bring the rigor of objective quantitative analysis to realms that were once considered fundamentally subjective, including literature and the study of social groups.

"For the first time, we have large data sets from places like Facebook and Twitter that we can analyze with high-powered computers and get meaningful results," said Paulo Shakarian, a computer scientist at the United States Military Academy at West Point, who is working on an algorithm to predict the location of insurgent weapons caches. "Iraq and Afghanistan are the very first conflicts where we have been collecting as much data as we possibly can."

In the case of the WikiLeaks data, the researchers sought to find a general pattern to the violence in Afghanistan and use it to predict how violence would change in each province in 2010 — the year President Obama increased the number of U.S. troops in the country.

"The model we employed is both complex and simple," said Guido Sanguinetti, an expert in computational sciences at the University of Edinburgh in Scotland and the study's senior author. "It doesn't take in any knowledge of military operations or political events, and it treats all types of violence exactly the same, whether it's a stop-and-search or a big battle."

Even with these ostensibly key details missing, the researchers found that they could predict 2010's events with striking accuracy.

And the model wasn't tripped up by Obama's decision to send 30,000 additional troops, which introduced a new dimension to the Afghanistan conflict.

"Our findings seem to prove that the insurgency is self-sustaining," Sanguinetti said. "You may throw a large military offensive, but this doesn't seem to disturb the system."

The study authors said they were most surprised that the model could predict activity even in Afghanistan's relatively quiet northern provinces, where there were fewer data points available to analyze.

"This shows that the escalation we see isn't just attributed to the noise in the data," said study leader Andrew Zammit Mangion, a computational sciences researcher at the University of Edinburgh. Instead, he said, patterns existed nearly everywhere.

Michael Ward, a political scientist at Duke University who has shown that location data can improve predictions of conflicts, said the study pointed the way to future research.

"Suppose you could say, 'This is the effect on violence if you build different types of infrastructure,' " he said. "They don't do that, but they've set up the framework to do it."

The study also shows why it's important to make as much data public as possible, Ward said. Without WikiLeaks, he said, a study like this would have been far more difficult to carry out.

Clionadh Raleigh of Trinity College Dublin, who uses data to predict violence in Africa based on factors such as the outcomes of local elections, said the Afghanistan model could be made even better by including variables such as the political party in power.

"Violence, in general, is a really good predictor of future violence," she said. But even better would be "to figure out what stops the cycle of conflict."

Quantitative rigor is making its way into some surprising fields of study. In 2010, just a few months after the WikiLeaks data dump, Google released a database of every single word contained in thousands of books published between 1800 and 2000 — about 4% of all books ever printed. That has enabled some intrepid researchers to close in on the final frontier: Studying literature with advanced math.

In a study published last year in Science, experts from Harvard University and Google were able to detect evidence of censorship regarding controversial historical figures and events, such as early Soviet official and Stalin foe Leon Trotsky and the 1989 Tiananmen Square massacre in China.

"That's what this digital humanities focus is being driven toward: uncovering trends in data that have just never been available before," Raleigh said.
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Afghanistan snow leopards tagged, followed

Wakhan Corridor, July 24 (Newswire): Conservationists say two snow leopards were captured, fitted with satellite collars and released in the first such effort in Afghanistan.
 
Researchers with the Wildlife Conservation Society and Afghan veterinarians successfully captured, tagged and released the male snow leopards on May 27 and June 8 respectively, the society said in a release.
 
After each cat was weighed, measured, fitted with a satellite collar and had DNA samples taken, they were released and headed up into the Hindu Kush Mountains, conservationists said.
 
The first snow leopard captured, dubbed Pahlawan, has traveled more than 75 miles since being release, while the second cat, Khani Wakhai, has traveled more than 90 miles, satellite tracking revealed.
 
Found in 12 nation in Asia from Russia to Nepal, an adult snow leopard stands about 2 feet tall at the shoulder, and weighs between 60 and 120 pounds, with large paws ideally adapted to both rocky terrain and deep snow drifts.
 
"These captures are sensational," David Lawson, the society's Afghanistan country director, said.
 
"They are also a real tribute to the knowledge of the local community rangers and the success of our recent camera trapping efforts, which enabled the team to select spots that were known to be frequented by snow leopards."
 
Snow leopards have been categorized as an endangered species since 1972.
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The tender poetry of... the Taliban?

Kabul, July 24 (Newswire): Taliban poetry. The very idea may make some people snort. How can a group of mountain fighters who spent weeks shelling the face off stone Buddha statues and ordered millions of Afghan women to cover their faces under burqas, have anything of value to say about beauty?


Following a release in Britain a few months ago, "The Poetry of the Taliban" has been released this week in the United States, published by Columbia University Press.

I will let the literary set decide what is good poetry or bad poetry, although the estimable New-Delhi-based British historian William Dalrymple did have this to say:


"This extraordinary collection is remarkable as a literary project – uncovering a seam of war poetry few will know ever existed, and presenting to us for the first time the black turbaned Wilfred Owens of Wardak. But it is also an important political project: humanizing and giving voice to the aspirations, aesthetics, emotions, and dreams of the fighters of a much-caricatured and still little-understood resistance movement that is about to defeat yet another foreign occupation."

For those who have spent any length of time at all in Afghanistan, it will come as no surprise that Afghans are a poetic people.

As a young war correspondent in Jalalabad, one of my keenest memories was not a night of bullets flying and prayers spoken, but rather a night of poetry. We had just eaten a meal of rice and lamb, and my host and his cousins and friends were passing around a watering can to wash their hands.

And then it began: One gentleman among us recited a love poem of startling romantic sincerity. Then came another poem about the feebleness of human character. Then another about a fickle lover. Then another about the terrors of battle, and the loss of a loved one. Some of these poems were ancient, but most had been written by the men who were reciting them, all doctors and merchants and political science students. And there wasn't a cheap and dirty limerick in the lot.

My hosts turned to me, and I had nothing to offer, except appreciation for the beauty of their words.

Today, the release of this Taliban poetry book is an odd echo of that evening session. Odd, because I had probably assumed that poetry only occurred among the semi-elite, and especially those of the enlightened democratic sort who would have been fighting against the Taliban. But poetry is a potent weapon that only gets stronger in the hands of someone faced with an impossible cause and a powerful enemy.

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Conservatives work out Supreme Court anger, betrayal through song

Washington, July 24 (Newswire): Conservatives who feel betrayed by Chief Justice John Roberts' decision to uphold President Barack Obama's health care law last month are seeking solace in the power of song.
 
Kathleen Burch, an intern for the conservative Media Research Center, belts out her pain in a parody of Gotye's "Somebody that I Used to Know."
 
"You didn't have to stoop so low, listen to the liberal justices and change your opinion," she sings in the video above. "Now you're just some justice that I used to know."
 
Meanwhile, Ilya Shapiro of the libertarian Cato Institute think tank re-imagined the impossibly catchy "Call Me Maybe" song as a diatribe against the fickleness of Roberts:
 

When you came onto the Court
 I thought you so rad
 My man-crush so bad
 My man-crush so, so bad
 
Now thanks to you I'll pay this tax
 It made me so mad
 But now I'm just sad
 It makes me so, so sad
 
Republicans' opinion of Chief Justice John Roberts has plummeted since he sided with the four liberal justices in June to uphold President Obama's health care law, according to a Gallup poll out. Nearly 70 percent of Republicans approved of Roberts when he was nominated by President Bush in 2005, but now, only 27 percent of Republicans say they approve of the chief justice.

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Some Florida residents protesting ‘mutant mosquitoes’ plan

Washington, July 24 (Newswire): More than 100,000 residents in Key West have signed a petition against introducing several thousand genetically modified mosquitoes into the Florida ecosystem.
 
The Christian Post reports that the 5,000 to 10,000 modified male insects are designed by British company Oxitec to die off more quickly. The hope is that when they reproduce with the local mosquito population, it would eventually reduce the rates of dengue fever.
 
However, Mila de Mier says that the long-term effects of the so-called "mutant mosquitoes" are unknown and launched an online petition that she plans to deliver to Gov. Rick Scott and other officials once it reaches 150,000 signatures.
 
"There are more questions than answers and we need more testing to be done," de Mier writes on the petition site, claiming that dengue fever has been absent from Key West since 2010.
 
Although dengue fever has unpleasant symptoms, the U.S. National Library of Medicine says it is not considered a deadly disease. Its effects are commonly treated with Tylenol and fluids.
 
The IBTimes notes that concerns over the plan have tapped into a larger debate over genetically modified foods.
 
"We won't be lab rats just so this company can make money. Oxitec says we have to do this to control mosquitoes, but it's just not true," de Mier told Orlando's WKMG-TV. "Other methods of mosquito control are working. We don't need to gamble with mutant mosquitoes."
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Bank of America, Syncora settle mortgage fraud lawsuit

New York, July 24 (Newswire): Bank of America Corp (BAC) has agreed to pay $375 million to settle a case brought by bond insurer Syncora Guarantee over toxic mortgage-backed securities at the center of the 2008 financial crisis.

Syncora sued Bank of America in 2009 to recover losses on securities transactions based on home loans made by Countrywide Financial, which was bought by Bank of America in 2008. Syncora said it was duped into insuring the mortgage-backed securities and that Countrywide misrepresented the quality of the underlying mortgages.

Syncora, a unit of Syncora Holdings Ltd announced the settlement in a statement.

Jonathan Rosenberg, an attorney for Bank of America, did not immediately return a call seeking comment.

Home loans such as those issued by Countrywide were at the center of the financial crisis. As loans became delinquent, mortgage-backed securities such as those insured by Syncora collapsed, helping to trigger a wider market meltdown.

In its lawsuit, Syncora claimed "a significant percentage" of mortgage loans underlying the securitizations did not comply with Countrywide's representations and warranties. The bond insurer sued for fraudulent inducement and breach of contract, seeking to recover money paid out on its policies as a result of the bad loans.

"Countrywide, consistent with its business practices at the time, systematically ignored its own underwriting guidelines and made imprudent loans that no reasonable underwriter would have made," Syncora said in its lawsuit.

As of May 2010, when an amended lawsuit was filed, Syncora had already paid more than $145 million in claims and had been given notice of another $257 million.

Rulings in the Syncora case and a similar lawsuit brought by bond insurer MBIA Inc (MBI) have set precedents for what bond insurers need to show to prove insurance fraud and breach of contract.

Syncora Guarantee has also sued other banks over false and misleading statements in connection with mortgage-backed securities, including JPMorgan Chase & Co over Bear Stearns & Co transactions.
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Ex-AIG's Greenberg case may be heard by NY high court

New York, July 24 (Newswire): New York state's highest court could hear securities fraud charges against former American International Group (AIG) chief Maurice "Hank" Greenberg and the insurance company's former chief financial officer, Howard Smith.

In a single-sentence order, the state's appellate division granted a motion by Greenberg and Smith to appeal its May 8 decision to send the case to trial.

The charges under one of New York's toughest laws, the 90-year-old Martin Act, may now be heard by the Court of Appeals, the state's highest court.

Greenberg and Smith deny the charges and have fought them under three New York State Attorney-Generals since they were accused in 2005 of involvement in a reinsurance scheme at AIG that masked the company's true financial position.

AIG was bailed out by the federal government in the 2008 financial crisis.

Greenberg's lawyers at Boies, Schiller & Flexner said in a statement that they would challenge parts of the Martin Act, believing it is pre-empted by federal statutes.

The Act came into force in 1921. It gives a prosecutor extraordinary powers and discretion in financial fraud cases that exceed those of any other U.S. state.

"The appeal will determine the validity of the Martin Act, which the New York Attorney General and his predecessors have used prodigiously, but with questionable legality in light of conflicting federal standards," the lawyers' statement said.

James Freedland, a spokesman for New York Attorney General Eric Schneiderman, said the office was "confident the court of appeals will uphold the lower court's decision and we look forward to trying this case to hold the defendants accountable for perpetrating a major reinsurance scheme to defraud investors."

The case is People of the State of New York v Greenberg in the New York State Appellate Division, First Department, Motion Nos. M-2368 and M-2558
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Fed likely to ease by September: Goldman

New York, July 24 (Newswire): The U.S. Federal Reserve could ease monetary policy when policymakers meet in August or September, although a large move is more likely to come only after the elections later in the year, Goldman Sachs said in a report.


In a testimony before the Senate Banking Committee, Federal Reserve Chairman Ben Bernanke offered no new hints that the central bank is planning more easing, but repeated a pledge that the Fed "is prepared to take further action as appropriate to promote stronger economic recovery."

"While we think that a modest easing step is a strong possibility at the August or September meeting, we suspect that a large move is more likely to come after the election or in early 2013, barring rapid further deterioration in the already-cautious near term Fed economic outlook," Goldman Sachs (GS) economist Andrew Tilton said in a report.
•Why Fed Can't Save Economy, Or Markets 'On Its Own'

Tilton said that the lack of inclusion of easing options in Bernanke's prepared testimony suggested a lower probability of a big easing step at the August monetary policy meeting. Extending the current guidance that rates will remain "exceptionally low...at least through late 2014" appears the path of least resistance should the Fed decide to ease policy in August or September, the report said.

"The bottom line: our base-case expectation is for an extension of the rate guidance by September, with a larger easing action (asset purchases or a "credit easing" program) in December or early 2013," Tilton said in the report.

The U.S. central bank has held overnight borrowing costs near zero since December 2008 and has bought $2.3 trillion in government and mortgage-related debt to push long-term interest rates lower.

As the economic recovery faltered, the Fed promised to hold rates at rock bottom levels until at least 2014, and, at its June meeting, it extended a program to lengthen the average maturity of bonds in its portfolio to depress long-term borrowing costs.
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Dell CEO upbeat on China despite slowdown

Aspen, July 24 (Newswire): Dell Inc Chief Executive Officer Michael Dell said he remains upbeat about emerging markets such as China, its largest market outside the United States, despite "challenges" and a business slowdown.

China, which accounts for about $5 billion of Dell's annual revenue, has for years picked up the slack as personal computer spending waned in developed markets. Now the world's No.2 economy is decelerating also, though its growth still outpaces that of most countries.

"We are bullish on markets like China, India, Brazil," Dell said in an interview. The company's founder added that it could also count on Africa, which accounts for $1 billion in annual revenue that is expected to grow exponentially.

But "there are some challenges in China," the CEO told executives and investors at the Fortune Brainstorm tech conference in Aspen Colorado. "Emerging markets are a big deal for us."

Asked if he saw a business slowdown in China, he said: "That would be an accurate statement."

Dell's board will meet in September in China, though the CEO would not talk about what else might transpire there. The world's second-largest economy is growing at its slackest pace in more than three years, according to official data released last week.

China and other emerging markets have long been bright spots for Dell, Hewlett-Packard Co and other personal computer makers struggling to sustain growth as smartphones and tablets eat into sales. Europe's crisis is expected to curtail PC-buying further in the second half.

Asia's top economy remains at the forefront of global growth, and its PC market is expected to far outpace that of the worldwide industry.

But in past weeks, corporations such as microprocessor maker Advanced Micro Devices and chip geam producer Applied Materials have warned that growth in the resilient Chinese market too was trending lower.

While the tablet market remains small, demand for the devices is growing much more quickly than for PCs. Shipments of tablets, including Apple's iPad, are expected to grow 90 percent this year, according to IHS iSuppli.

Despite that exponential growth, the CEO wants to stick to a strategy of serving corporate PC customers. That includes developing both hardware and software to meet their needs.

"We continue to see PCs as an important part of our enterprise business. We are very focused on enterprise solutions and PCs are an important part of that," he said.

"We are building a pretty substantial software business."
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GM eyes big campaign as Cadillac ATS takes on BMW

Detroit, July 24 (Newswire): General Motors' Cadillac brand on Wednesday launched one of its most crucial marketing campaigns since the automaker emerged from bankruptcy as it takes aim at BMW's 3-series in the heart of the U.S. luxury car market with its new ATS sedan.

GM has lacked a small luxury car in recent years -- a segment that accounts for 60 percent of the luxury market and one that also garners younger users.

As the smallest and least expensive Cadillac, the 2013 ATS is key to GM's hopes of making Cadillac more of a global luxury brand. It goes on sale in the U.S. market next month, following on from the launch of the large XTS sedan last month.

With a starting price of just under $34,000, the ATS is a direct challenge to BMW and Daimler AG's Mercedes-Benz C-Class.

"The task of ATS is very ambitious, going into the largest luxury segment against a brand like 3-Series that's dominated the segment," said Cadillac global marketing director James Vurpillat.

The marketing campaign begins with a 2-minute video on YouTube and will include 10 TV ads during the Olympic Games in London, starting with the opening ceremony on July 27.

The campaign dubbed "Cadillac ATS vs. the World" features the car being driven in exotic locales such the winding roads of Morocco's Atlas Mountains or through the remote hand-carved Guoliang Tunnel in China.

Cadillac officials declined to provide the marketing budget for the ATS launch, but said it was on par with the introduction of the CTS car two years ago when the brand spent more than $297 million on ads for the U.S. market according to Kantar Media.

However, GM, which filed for bankruptcy in 2009 as part of a $50 billion US taxpayer-funded bailout, has failed in the small luxury segment before. In the early 1980s, it launched the Cadillac Cimarron, which Time magazine in 2007 called one of the 50-worst cars ever built.

Brand image remains perhaps the most crucial asset in the luxury car market, where it can take a long time and a lot of money to overhaul consumer perceptions, analysts said.

The average age for Cadillac drivers in the first half of the year was 58 years old, according to CNW Research. That's nine years older than BMW but one year younger than Mercedes.

That is an improvement for Cadillac from 1995, when the average age was about 63. The Escalade SUV's reception from hip-hop artists and the success of its CTS model has helped upend Cadillac's "geezermobile" image and that trend should continue with the newer models, according to Art Spinella, president of market researcher CNW.

"Anything that's more sporty is going to end up dragging that number down quite a bit," he said.

The ATS will be built on a new rear-wheel drive platform, but will also come in an all-wheel drive version.
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AMR merger would strengthen its oneworld partners: IAG chief

Washington, July 24 (Newswire): A potential merger between American Airlines and US Airways would strengthen, not harm, its partners British Airways and Iberia, the European airlines group's chief said on Tuesday.

Willie Walsh, chief executive of the International Airlines Group (IAG) - the holding company for the two airlines and UK airline BMI - told a meeting of aviation industry representatives he supports any consolidation plan that will strengthen its oneworld alliance partner American Airlines.

With 11 participating airlines, oneworld is one of the world's three largest global airline alliances, which enables member airlines to offer customers more service across a larger global network.

American parent company AMR Corp is trying to exit Chapter 11 bankruptcy protection, which it filed for last November, by the end of the year.

Tempe, Arizona-based US Airways Group Inc (LCC) has expressed strong interest in a merger with American and has been courting AMR creditors.

"I've never been concerned when people have talked about this as representing a potential threat to oneworld or IAG," Walsh told reporters after a speech hosted by the Washington International Aviation Club.

"Quite the opposite - I see it, and I've always seen it, as a great opportunity for IAG and for oneworld because, without question, American will be stronger and will be better."

Walsh added that IAG would also invest directly in the third-biggest U.S. airline after it emerges from bankruptcy, whether it remains a standalone or merges with a partner.

"What we've said is that we are willing to invest in American, particularly a restructured American, if they would welcome that," he said. "We would only do it if they saw it as a positive development."


Walsh said a merger with another airline will be inevitable for American.

"There will be consolidation - that's my view. Whether its US Airways and American together, I don't know," he said.

Unlike other possible partners, the US Airways network "complements" the American network, Walsh added.

While he admires US Airways chief Doug Parker's aggressive and public push to merge his airline with American in the near term, Walsh said American's desire to consider merger options after exiting from bankruptcy is "absolutely right."

He said American Chief Executive Tom Horton "will have a stronger hand to play with after he has exited (chapter 11)."

"If you look at it historically, most of the consolidation has happened after exiting from chapter 11," he told reporters.

In a statement on Tuesday, American reiterated comments made by Horton to employees last week that the carrier plans to consider a range of alternatives, including possible mergers, to make it stronger.

In addition to a potential US Airways tie-up, American is said to be weighing mergers with JetBlue Airways Corp (JBLU), Alaska Air Group Inc (ALK), Republic Airways Holdings Inc's (RJET) Frontier Airlines and Virgin America.

IAG's Walsh said that regardless of what American decides, the U.S. airline industry will continue to see large-scale tie-ups.

"Whatever happens with American will trigger some further consolidation within the industry. All of that will be positive," he said.

Spanish-listed IAG was formed in January 2011 as the holding company of Spanish airline Iberia and the UK's second-largest airline BMI.
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Cellular services remain suspended in north Kashmir

Srinagar, July 24 (Newswire): In occupied Kashmir, the residents of North Kashmir's Baramulla district are facing tremendous problems due to absence of cellular services snapped last month following the killing of two innocent youth by Indian police.

The services of different companies were suspended in the district on June 28 by the occupation authorities. Thousands of subscribers in Baramulla, Sopore, Sangrama, Rafiabad and other adjoining areas have been running from pillar to post to know when their mobiles would start ringing again.

"The occupation authorities have punished the entire population to hide their own failures," the local people while talking to the media persons said. "They should have blocked services of those persons whom they considered threat to law and order situation," they added.

A wave of anger has swept among people in North Kashmir over the ban, which has badly hampered fruit business in the territory.

Khursheed Ahmed, a fruit grower, said that the businessmen had no idea about the market trends of apples in other parts of the territory due to the arbitrary and illogical move.

"The entire economy of people in this region is dependent on fruit industry. It seems that government is hell-bent upon destroying our economy by snapping the mobile services," he said, adding, "If the services are not restored forthwith we will take to roads."

Meanwhile, the cellular companies have disconnected thousands of mobile phones in the Valley.
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Imposition of curfew, restrictions in IHK condemned

Islamabad, July 24 (Newswire): The All Parties Hurriyet Conference Azad Jammu and Kashmir Chapter (APHC-AJK) leader, Altaf Hussain Wani has condemned the authorities for imposing curfew and restrictions in occupied Kashmir.

Altaf Wani in a statement issued in Islamabad said that the continued curfew, restrictions and use of force by Indian troops were sheer violation of fundamental human rights.

He said that the troops were even preventing the people from offering prayers. "The authorities are using excessive force to crush the Kashmiris' liberation movement," he deplored.

Lauding the people of the occupied territory for rendering matchless sacrifices to achieve their right to self-determination, he asked them to keep unity among their flanks to take the movement to its logical end.

Condemning the continued illegal detention of ailing APHC leader, Nayeem Ahmed Khan, he appealed the international community to impress upon India to repeal the draconian laws including Armed Forces Special Powers Act, Public Safety Act and immediately release all the pro-liberation leaders and activists.
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Agitation a referendum against Indian state terrorism: TEH

Srinagar, July 24 (Newswire): In occupied Kashmir, the Tehreek-e-Hurriyet Jammu and Kashmir has described the ongoing agitation in the territory as a referendum against Indian state terrorism.

The spokesman of Tehreek-e-Hurriyet Jammu and Kashmir in a statement issued in Srinagar asked India to realise the ground reality and take solid steps for resolving the Kashmir dispute.

He praised the people's sentiment for freedom and thanked them for participation in protest demonstrations against Indian state terrorism in the occupied territory.

The spokesman said that India should start demilitarisation, revoke all black laws and release all illegally detained Hurriyet leaders including Syed Ali Gilani, Shabbir Ahmad Shah, Muhammad Ashraf Sehrai, Mian Abdul Qayoom, Ghulam Nabi Shaheen, Firdous Ahmad Shah, Muhammad Yousuf Mujahid, Abdul Aziz Dar and Bilal Sidiqui.
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Biologists develop machine to remove viruses from blood

Islamabad, July 24 (Newswire): Infectious disease experts designed a machine called the hemopurifier.

It works much like a dialysis machine, using thin fibers to capture and remove viruses from the blood it filters. The machine requires the drawing of blood through an artery, which is sent through a tube into the machine, then back into the body. It can treat a number of illnesses.

Every day, 14,000 people are infected with HIV, the virus that leads to AIDs. There's no cure, but now a breakthrough -- a machine that could clean blood, keeping more and more people alive longer.

"I remember lying in bed thinking, 'I am going to die. I'm going to die. I feel so sick.' And I remember thinking laying in that bed, 'And I know exactly what it is,'" HIV patient John Paul Womble, told Ivanhoe. HIV could kill Womble.

He watched his father die from the virus and now he is living the rest of his life with it. "I've got to live as healthy as I can, but this virus is not going to control me," he says. Now, a machine could help clean Womble's infected blood and keep him healthier, longer.

"It's designed to mimic the natural immune response of clearing viruses and toxins before cells and organs can be infected," Jim Joyce chairman and CEO of Aethlon Medical in San Diego, told Ivanhoe. Developed by infectious disease and biodefense experts, the hemopurifier works like a dialysis machine. Antibodies on these spaghetti-like fibers capture and remove viruses as blood filters through it.

"Your entire circulation flows through the cartridge about once every eight minutes," Joyce explains. The entire process takes less than a few hours. It could help patients infected with HIV, hepatitis C, as well as people with the measles, mumps and the flu. "The cartridge is able to selectively capture viruses."

A larger version of the machine would be used in a hospital, but a smaller one could be taken to emergencies. It could be a life-safer against the avian flu or bio-weapons like Ebola and small pox, giving people a chance to survive a deadly attack, whether it's from a terrorist or a virus.

"I don't have to be afraid," Womble says. "I have a virus. I've got to do something about that virus. I've got to treat that virus. I've got to live as healthy as I can." The hemopurifier is also a leading treatment candidate to protect United States civilian and military populations from bioterror threats and emerging pandemic threats like the bird flu and dengue fever that are untreatable with drugs and vaccines.
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Chromosomal test by molecular biologists determines cancer spread

Islamabad, July 24 (Newswire): A new biopsy test, created by molecular biologists, can tell ocular melanoma patients if theirs is the kind that will spread. Using very thin needles, surgeons collect cells from tumors and analyze them.

If tumors are missing a copy of chromosome three, patients are at high risk of having their cancer spread. While there's no cure for ocular melanoma, patients who are at higher risk can be followed more closely and put on experimental treatments.

Ocular melanoma, or eye cancer, is a serious disease that affects about 2,000 Americans each year. Roughly half of patients will die from the cancer because their tumor spreads to other areas of the body. Now, a new test can tell patients if they're looking at life ... or death.

Just like everyone, Susan Izanstark-Rosenthal relies on her eyes every second of every day. "I'm an attorney, and I read and write all day long," she says.

But about a year ago, she didn't know if she'd be able to see out of her left eye ever again. Rosenthal was diagnosed with ocular melanoma. Surgery followed.

"It was very scary, and I didn't know when I woke up if I'd be able to see in the other eye," she says. Even scarier -- she found out she could die if her cancer spread. Ocular oncologist Tara Young, says a new biopsy test can tell patients if their tumor is the kind that will spread.

"It represents the first step that we've been able to make in a long time with this cancer," Young, of the Jules Stein Eye Institute at UCLA, tells DBIS.

Using very thin needles, surgeons collect cells from tumors and analyze them. If tumors are missing a copy of chromosome three, patients are at high risk of having their cancer spread. If tumors are normal, they have a very low risk.

"If someone could tell you that you were gonna go and die of your cancer, I think that most people want that information and that knowledge, so that they can just take a little bit more control over their lives," Young says.

Only a handful of medical centers across the country are performing the eye biopsy technique. While there's no cure for ocular melanoma, patients who are at higher risk can be followed more closely and put on experimental treatments. She says so far, all of her patients have wanted to know the results of their biopsy.

Rosenthal wasn't missing a copy. It's a great relief for her -- and her daughter. "It's given me, once again, a reminder that you need to appreciate every day and be very grateful for what you have," Rosenthal says.
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Biophotonic tools reveal real-time dynamics in living color

Islamabad, July 24 (Newswire): Apoptosis, programmed cell death, is essential to normal development, healthy immune system function, and cancer prevention.

The process dramatically transforms cellular structures but the limitations of conventional microscopy methods have kept much about this structural reorganization a mystery.

Now, in research featured on the cover of the current issue of Proceedings of the National Academy of Sciences, University at Buffalo scientists have developed a biophotonic imaging approach capable of monitoring in real-time the transformations that cellular macromolecules undergo during programmed cell death.

The work could help realize the potential of customized molecular medicine, in which chemotherapy, for example, can be precisely targeted to cellular changes exhibited by individual patients. It can also be a valuable drug development tool for screening new compounds.

"This new ability provides us with a dynamic mapping of the transformations occurring in the cell at the molecular level," says study co-author Paras N. Prasad, PhD, executive director of the UB Institute for Lasers, Photonics and Biophotonics (ILPB) and SUNY Distinguished Professor in the departments of Chemistry, Physics, Electrical Engineering and Medicine. "It provides us with a very clear visual picture of the dynamics of proteins, DNA, RNA and lipids during the cell's disintegration."

Prasad notes that molecular medicine, in which treatments or preventive measures can be tailored to cellular properties exhibited by individual patients, depends on much better methods of visualizing what's happening during critical cellular processes.

"This research helps improve our understanding of cellular events at the molecular level," he says. "If we know that specific molecular changes constitute an early signature of a disease, or what changes may predispose a patient to that disease, then we can take steps to target treatment or even prevent the disease from developing in the first place."

To capture the cellular images, the interdisciplinary UB team of biologists, chemists and physicists, led by Prasad, utilized an advanced biophotonic approach that combines three techniques: a nonlinear, optical imaging system (CARS or Coherent anti-Stokes Raman scattering), TPEF (two-photon excited fluorescence), which images living tissue and cells at deep penetration and Fluorescence Recovery after Photobleaching to measure dynamics of proteins.

"For the first time, this approach allows us to monitor in a single scan, four different types of images, characterizing the distribution of proteins, DNA, RNA and lipids in the cell," says Aliaksandr V. Kachynski, PhD, research associate professor at the ILPB and co-author.

The resulting composite image integrates in one picture the information on all four types of biomolecules, with each type of molecule represented by a different color: proteins in red, RNA in green, DNA in blue and lipids in grey, as shown on the PNAS cover.

Multiplex imaging provided new information on the rate at which proteins diffuse through the cell nucleus, the UB scientists say.

Before apoptosis was induced, the distribution of proteins was relatively uniform, but once apoptosis develops, nuclear structures disintegrate, the proteins become irregularly distributed and their diffusion rate slows down, says Artem Pliss, PhD, research assistant professor at the ILPB and co-author on the paper.

"This research gives us the unique ability to study and improve our understanding of individual subcellular structures and the transformations they go through," says Pliss.

Such precise information will be especially useful for monitoring how specific cancer drugs affect individual cells.

"For example, say drug therapy is being administered to a cancer patient; this system will allow for the monitoring of cellular changes throughout the treatment process," notes Kachynski. "Clinicians will be able to determine the optimal conditions to kill a cancer cell for the particular type of disease. An improved understanding of the drug-biomolecule interactions will help discover the optimal treatment doses so as to minimize side effects."

Andrey Kuzmin, PhD, research assistant professor at the ILPB and co-author, adds that a new paper from the UB team, forthcoming in Biophysical Journal, further extends this work.

"The benefits of the UB multiplex imaging system and its molecular selectivity have been further extended into a new fundamental cellular study, structural reorganization throughout the mitotic cell cycle," he says.

The work was supported by a grant from the John R. Oishei Foundation of Buffalo, N.Y.

The researchers are active participants in the strategic strength in Integrated Nanostructured Systems identified in the UB 2020 strategic plan for academic, research and service excellence.
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